High concentrations of glucose suppress etoposide-induced cell death of B-cell lymphoma through BCL-6

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Title
High concentrations of glucose suppress etoposide-induced cell death of B-cell lymphoma through BCL-6
Author(s)
Yan Shao; C C Ling; X Q Liu
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 450, no. 1, pp. 227-233
Publication Year
2014
Abstract
Glucose is potentially a factor in the resistance to chemotherapy of B-cell lymphomas. In this study we investigated the expression of the glucose induced transcription factor Bcl-6 and the underlying mechanism by which it suppresses B-cell lymphoma cell death. Glucose was found to prevent etoposide-induced tumor cell death. BCL-6 expression was induced by glucose but down-regulated by etoposide. BCL-6 expression was regulated by the interaction of VDUP1 and p53. The molecular mechanism by which glucose prevented etoposide-induced tumor cell death was shown to involve the BCL-6 mediated caspase pathway. Our data suggest that glucose-induced BCL-6 overexpression could abrogate the etoposide chemotherapy effect on tumor cell death.
Keyword
B-cell lymphomaBCL-6ChemotherapyEtoposideGlucose
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2014.05.096
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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