DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y Park | - |
dc.contributor.author | H S Ryu | - |
dc.contributor.author | H K Lee | - |
dc.contributor.author | J S Kim | - |
dc.contributor.author | Ji Eun Yun | - |
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | B Y Hwang | - |
dc.contributor.author | J T Hong | - |
dc.contributor.author | Y Kim | - |
dc.contributor.author | S B Han | - |
dc.date.accessioned | 2017-04-19T09:55:33Z | - |
dc.date.available | 2017-04-19T09:55:33Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | 10.1016/j.intimp.2014.07.023 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12139 | - |
dc.description.abstract | Sesquiterpenoid tussilagone (TUS) has a variety of pharmacological activities, such as anti-oxidant, anti-cancer, and anti-inflammatory activities. In this study, we investigated the effects of TUS on dendritic cell (DC) functions and the underlying mechanisms. TUS inhibited lipopolysaccharide (LPS)-induced activation of DCs, as shown by decrease in surface molecule expression, cytokine production, cell migration, and allo-T cell activation. In addition, TUS inhibited LPS-induced activation of NF-κB, MAPKs, and IRF-3 signalings in DCs, although it did not directly affect kinase activities of IRAK1/4, TAK1, and IKK, which suggests that TUS might indirectly inhibit TLR signaling in DCs. As a critical mechanism, we showed that TUS activated heme oxygenase-1 (HO-1), which degrades heme to immunosuppressive products, such as carbon monoxide and bilirubin. HO-1 inhibitor reversed the inhibitory activity of TUS in DCs. In conclusion, this study suggests that TUS inhibits DC function through the induction of HO-1. | - |
dc.publisher | Elsevier | - |
dc.title | Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1 | - |
dc.title.alternative | Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1 | - |
dc.type | Article | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 408 | - |
dc.citation.startPage | 400 | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Ji Eun Yun | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.alternativeName | 박윤수 | - |
dc.contributor.alternativeName | 류화선 | - |
dc.contributor.alternativeName | 이홍경 | - |
dc.contributor.alternativeName | 김지성 | - |
dc.contributor.alternativeName | 윤지은 | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 황방연 | - |
dc.contributor.alternativeName | 홍진태 | - |
dc.contributor.alternativeName | 김영수 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, vol. 22, no. 2, pp. 400-408 | - |
dc.identifier.doi | 10.1016/j.intimp.2014.07.023 | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | Heme oxygenase-1 | - |
dc.subject.keyword | MAPKs | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Tussilagone | - |
dc.subject.local | Dendritic cell | - |
dc.subject.local | Dendritic cells (DC) | - |
dc.subject.local | dendritic cells | - |
dc.subject.local | Dendritic cells (DCs) | - |
dc.subject.local | Dendritic cells | - |
dc.subject.local | dendritic cells (DC) | - |
dc.subject.local | dendritic cell | - |
dc.subject.local | Heme oxygenase-1 | - |
dc.subject.local | Heme-oxygenase 1 | - |
dc.subject.local | MAPK | - |
dc.subject.local | MAPKs | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | tussilagone | - |
dc.subject.local | Tussilagone | - |
dc.description.journalClass | Y | - |
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