Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1

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dc.contributor.authorY Park-
dc.contributor.authorH S Ryu-
dc.contributor.authorH K Lee-
dc.contributor.authorJ S Kim-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorB Y Hwang-
dc.contributor.authorJ T Hong-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T09:55:33Z-
dc.date.available2017-04-19T09:55:33Z-
dc.date.issued2014-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2014.07.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12139-
dc.description.abstractSesquiterpenoid tussilagone (TUS) has a variety of pharmacological activities, such as anti-oxidant, anti-cancer, and anti-inflammatory activities. In this study, we investigated the effects of TUS on dendritic cell (DC) functions and the underlying mechanisms. TUS inhibited lipopolysaccharide (LPS)-induced activation of DCs, as shown by decrease in surface molecule expression, cytokine production, cell migration, and allo-T cell activation. In addition, TUS inhibited LPS-induced activation of NF-κB, MAPKs, and IRF-3 signalings in DCs, although it did not directly affect kinase activities of IRAK1/4, TAK1, and IKK, which suggests that TUS might indirectly inhibit TLR signaling in DCs. As a critical mechanism, we showed that TUS activated heme oxygenase-1 (HO-1), which degrades heme to immunosuppressive products, such as carbon monoxide and bilirubin. HO-1 inhibitor reversed the inhibitory activity of TUS in DCs. In conclusion, this study suggests that TUS inhibits DC function through the induction of HO-1.-
dc.publisherElsevier-
dc.titleTussilagone inhibits dendritic cell functions via induction of heme oxygenase-1-
dc.title.alternativeTussilagone inhibits dendritic cell functions via induction of heme oxygenase-1-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number2-
dc.citation.endPage408-
dc.citation.startPage400-
dc.citation.volume22-
dc.contributor.affiliatedAuthorJi Eun Yun-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName박윤수-
dc.contributor.alternativeName류화선-
dc.contributor.alternativeName이홍경-
dc.contributor.alternativeName김지성-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName황방연-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 22, no. 2, pp. 400-408-
dc.identifier.doi10.1016/j.intimp.2014.07.023-
dc.subject.keywordDendritic cells-
dc.subject.keywordHeme oxygenase-1-
dc.subject.keywordMAPKs-
dc.subject.keywordNF-κB-
dc.subject.keywordTussilagone-
dc.subject.localDendritic cell-
dc.subject.localDendritic cells (DC)-
dc.subject.localdendritic cells-
dc.subject.localDendritic cells (DCs)-
dc.subject.localDendritic cells-
dc.subject.localdendritic cells (DC)-
dc.subject.localdendritic cell-
dc.subject.localHeme oxygenase-1-
dc.subject.localHeme-oxygenase 1-
dc.subject.localMAPK-
dc.subject.localMAPKs-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localtussilagone-
dc.subject.localTussilagone-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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