Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model = 시게스베키아의 항염증 및 항천식 효과

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dc.contributor.authorChan Mi Jeon-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorNa Rae Shin-
dc.contributor.authorJu Mi Hong-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorHui Seong Kim-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorP K Myung-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2017-04-19T09:55:33Z-
dc.date.available2017-04-19T09:55:33Z-
dc.date.issued2014-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2014.07.013ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12143-
dc.description.abstractSiegesbeckia glabrescens (SG) is a plant growing in Korea that is used as a traditional medicine for various inflammatory diseases. In this study, we investigated the protective effects of SG extract on allergic asthma in an ovalbumin (OVA)-induced asthma murine model and lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Female BALB/c mice were sensitized by intraperitoneal injection of OVA on days 0 and 14 and then challenged with OVA from days 21 to 23. SG (30 mg/kg) was administered by oral gavage 1 h before the OVA challenge. LPS-stimulated RAW264.7 cells were evaluated to determine their levels of nitric oxide (NO). The SG significantly reduced the number of inflammatory cells in bronchoalveolar lavage (BAL) fluid and also reduced IL-4, IL-5, IL-13, eotaxin and immunoglobulin E in OVA-sensitized/challenged mice. SG also effectively reduced airway inflammation and mucus overproduction in lung tissue in addition to decreasing the expression of iNOS and COX-2. In LPS-stimulated RAW264.7 cells, SG treatment significantly reduced the levels of NO. These findings indicate that SG effectively suppressed inflammatory responses, and its effects appear to be related to reduction in iNOS and COX-2 expression. Therefore, we suggest that SG may have potential use as a therapeutic agent for inflammatory diseases such as allergic asthma.-
dc.publisherElsevier-
dc.titleSiegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model = 시게스베키아의 항염증 및 항천식 효과-
dc.title.alternativeSiegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number2-
dc.citation.endPage419-
dc.citation.startPage414-
dc.citation.volume22-
dc.contributor.affiliatedAuthorChan Mi Jeon-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.affiliatedAuthorNa Rae Shin-
dc.contributor.affiliatedAuthorJu Mi Hong-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorHui Seong Kim-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName전찬미-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName신나래-
dc.contributor.alternativeName홍주미-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName김희성-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName명평근-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 22, no. 2, pp. 414-419-
dc.identifier.doi10.1016/j.intimp.2014.07.013-
dc.subject.keywordAsthma-
dc.subject.keywordCytokine-
dc.subject.keywordInducible nitric oxide synthase-
dc.subject.keywordInflammation-
dc.subject.keywordSiegesbeckia glabrescens-
dc.subject.localAsthma-
dc.subject.localasthma-
dc.subject.localCytokine-
dc.subject.localCytokines-
dc.subject.localcytokine-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localiNOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localnflammation-
dc.subject.localsiegesbeckia glabrescens-
dc.subject.localSiegesbeckia glabrescens-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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