Subcellular neural probes from single-crystal gold nanowires

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dc.contributor.authorM Kang-
dc.contributor.authorS Jung-
dc.contributor.authorH Zhang-
dc.contributor.authorTaejoon Kang-
dc.contributor.authorH Kang-
dc.contributor.authorY Yoo-
dc.contributor.authorJ P Hong-
dc.contributor.authorJ P Ahn-
dc.contributor.authorJ Kwak-
dc.contributor.authorD Jeon-
dc.contributor.authorN A Kotov-
dc.contributor.authorB Kim-
dc.date.accessioned2017-04-19T09:56:01Z-
dc.date.available2017-04-19T09:56:01Z-
dc.date.issued2014-
dc.identifier.issn1936-0851-
dc.identifier.uri10.1021/nn5024522ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12169-
dc.description.abstractSize reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain-computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of ∼100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a ∼50× reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subcellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.-
dc.publisherAmer Chem Soc-
dc.titleSubcellular neural probes from single-crystal gold nanowires-
dc.title.alternativeSubcellular neural probes from single-crystal gold nanowires-
dc.typeArticle-
dc.citation.titleACS Nano-
dc.citation.number8-
dc.citation.endPage8189-
dc.citation.startPage8182-
dc.citation.volume8-
dc.contributor.affiliatedAuthorTaejoon Kang-
dc.contributor.alternativeName강미정-
dc.contributor.alternativeName정승문-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeName강태준-
dc.contributor.alternativeName강호석-
dc.contributor.alternativeName유영동-
dc.contributor.alternativeName홍진표-
dc.contributor.alternativeName안재평-
dc.contributor.alternativeName곽주현-
dc.contributor.alternativeName전대종-
dc.contributor.alternativeNameKotov-
dc.contributor.alternativeName김봉수-
dc.identifier.bibliographicCitationACS Nano, vol. 8, no. 8, pp. 8182-8189-
dc.identifier.doi10.1021/nn5024522-
dc.subject.keywordBRAIN initiative-
dc.subject.keywordbrain-machine interface-
dc.subject.keywordelectrode miniaturization-
dc.subject.keywordepilepsy-
dc.subject.keywordgold nanowire-
dc.subject.keywordlong-term neural recordings-
dc.subject.keywordnanoelectrode-
dc.subject.keywordneural implants-
dc.subject.keywordneurodegenerative disease-
dc.subject.keywordneuroprosthetics-
dc.subject.keywordparalysis-
dc.subject.keywordsingle-neuron detection-
dc.subject.keywordsubcellular-sized implants-
dc.subject.localBRAIN initiative-
dc.subject.localbrain-machine interface-
dc.subject.localelectrode miniaturization-
dc.subject.localepilepsy-
dc.subject.localEpilepsy-
dc.subject.localGold nanowire-
dc.subject.localgold nanowire-
dc.subject.locallong-term neural recordings-
dc.subject.localnanoelectrode-
dc.subject.localneural implants-
dc.subject.localneurodegenerative disease-
dc.subject.localNeurodegenrative disease-
dc.subject.localNeurodegenerative diseases-
dc.subject.localNeurodegenerative disease-
dc.subject.localneuroprosthetics-
dc.subject.localparalysis-
dc.subject.localsingle-neuron detection-
dc.subject.localsubcellular-sized implants-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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