Nutrient control of Drosophila longevity

Cited 88 time in scopus
Metadata Downloads
Title
Nutrient control of Drosophila longevity
Author(s)
M Tatar; S Post; Kweon Yu
Bibliographic Citation
Trends in Endocrinology and Metabolism, vol. 25, no. 10, pp. 509-517
Publication Year
2014
Abstract
Dietary restriction (DR) extends the lifespan of many animals, including Drosophila melanogaster. Recent work with flies shows that longevity is controlled by the ratio of consumed protein relative to carbohydrates. Given that reduced insulin and/or insulin-like growth factor (IGF) and target of rapamycin (TOR) signaling increase Drosophila lifespan, these pathways are candidate mediators of DR. However, this idea has ambiguous experimental support. The Nutritional Geometric Framework (NGF), which dissects the impact of nutrient protein relative to carbohydrates, may provide an approach to resolving the roles for these pathways in DR. Nutrient sensing of protein and carbohydrate may occur in the fat body through signals to hypothalamic-like neurons in the fly brain and, thus, control secretion of insulin-like peptides that regulate longevity
Keyword
AgingDietary restrictionGeometric frameworkInsulin/IGF signalingLifespan extensionTOR
ISSN
1043-2760
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.tem.2014.02.006
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.