Expression of beta-catenin-interacting protein 1 (CTNNBIP1) gene is increased under hypothermia but decreased under additional ischemia conditions

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Title
Expression of beta-catenin-interacting protein 1 (CTNNBIP1) gene is increased under hypothermia but decreased under additional ischemia conditions
Author(s)
K Kwon; S W Kim; Kweon Yu; O Y Kwon
Bibliographic Citation
Biomedical Science Letters, vol. 20, no. 3, pp. 168-172
Publication Year
2014
Abstract
It has recently been shown that hypothermia treatment improves brain ischemia injury and is being increasingly considered by many clinicians. However, the precise roles of hypothermia for brain ischemia are not yet clear. In the present study we demonstrated firstly that hypothermia induced beta-catenin-interacting protein 1 (CTNNBIP1) gene expression and its expression was dramatically decreased under ischemic conditions. It was also demonstrated that hypothermia activated endoplasmic reticulum (ER) stress sensors especially both, the phosphorylation of eIF2α, and ATF6 proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia. These findings suggested that hypothermia controlled CTNNBIP1 gene expression under ischemia, which may provide a clue to the development of treatments and diagnostic methods for brain ischemia.
Keyword
HypothermiaIschemiaCTNNBIP1ER stress sensor
ISSN
2288-7415
Publisher
South Korea
DOI
http://dx.doi.org/10.15616/BSL.2014.20.3.168
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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