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- Expression of beta-catenin-interacting protein 1 (CTNNBIP1) gene is increased under hypothermia but decreased under additional ischemia conditions
- K Kwon; S W Kim; Kweon Yu; O Y Kwon
- Bibliographic Citation
- Biomedical Science Letters, vol. 20, no. 3, pp. 168-172
- Publication Year
- It has recently been shown that hypothermia treatment improves brain ischemia injury and is being increasingly
considered by many clinicians. However, the precise roles of hypothermia for brain ischemia are not yet clear. In the
present study we demonstrated firstly that hypothermia induced beta-catenin-interacting protein 1 (CTNNBIP1) gene
expression and its expression was dramatically decreased under ischemic conditions. It was also demonstrated that
hypothermia activated endoplasmic reticulum (ER) stress sensors especially both, the phosphorylation of eIF2α, and
ATF6 proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia.
These findings suggested that hypothermia controlled CTNNBIP1 gene expression under ischemia, which may provide
a clue to the development of treatments and diagnostic methods for brain ischemia.
- Hypothermia; Ischemia; CTNNBIP1; ER stress sensor
- South Korea
- Appears in Collections:
- Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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