9-O-butyl-13-(4-isopropylbenzyl)berberine, KR-72, is a potent antifungal agent that inhibits the growth of Cryptococcus neoformans by regulating gene expression

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dc.contributor.authorS Bang-
dc.contributor.authorH Kwon-
dc.contributor.authorH S Hwang-
dc.contributor.authorK D Park-
dc.contributor.authorSung Uk Kim-
dc.contributor.authorY S Bahn-
dc.date.accessioned2017-04-19T09:56:41Z-
dc.date.available2017-04-19T09:56:41Z-
dc.date.issued2014-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0109863ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12211-
dc.description.abstractIn this study we explored the mode or action of KR-72, a 9-O-butyl-13-(4-isopropylbenzyl)berberine derivative previously shown to exhibit potent antifungal activity against a variety of human fungal pathogens. The DNA microarray data revealed that KR-fl treatment significantly changed the transcription profiles of C. neoformans, affecting the expression of more than 2,000 genes. Genes involved in translation and transcription were mostly upregulated, whereas those involved in the cytoskeleton, intracellular trafficking, and lipid metabolism were downregulated. KR-fl also exhibited a strong synergistic effect with the antifungal agent FK506. KR-72 treatment regulated the expression of several essential genes, including ECM16, NOP14, HSP10 and MGE1, which are required for C. neoformans growth. The KR-72-mediated induction of MGEI also likely reduced the viability of C. neoformons by impairing cell cycle or the DNA repair system. In conclusion, KR-fl showed antifungal activity by modulating diverse biological processes through a mode of action distinct from those of clinically available antifungal drugs such as polyene and azole drugs.-
dc.publisherPublic Library of Science-
dc.title9-O-butyl-13-(4-isopropylbenzyl)berberine, KR-72, is a potent antifungal agent that inhibits the growth of Cryptococcus neoformans by regulating gene expression-
dc.title.alternative9-O-butyl-13-(4-isopropylbenzyl)berberine, KR-72, is a potent antifungal agent that inhibits the growth of Cryptococcus neoformans by regulating gene expression-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number10-
dc.citation.endPagee109863-
dc.citation.startPagee109863-
dc.citation.volume9-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.alternativeName방수현-
dc.contributor.alternativeName권효정-
dc.contributor.alternativeName황현숙-
dc.contributor.alternativeName박기덕-
dc.contributor.alternativeName김성욱-
dc.contributor.alternativeName반용선-
dc.identifier.bibliographicCitationPLoS One, vol. 9, no. 10, pp. e109863-e109863-
dc.identifier.doi10.1371/journal.pone.0109863-
dc.description.journalClassY-
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