Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus

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Title
Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus
Author(s)
Y I Kim; P N Q Pascua; H I Kwon; G J Lim; E H Kim; Sun Woo Yoon; S J Park; S M Kim; E J Choi; Y J Si; O J Lee; W S Shim; S W Kim; I P Mo; Y Bae; Y T Lim; M H Sung; C J Kim; R J Webby; R G Webster; Y K Choi
Bibliographic Citation
Emerging Microbes & Infections, vol. 3, pp. e75-e75
Publication Year
2014
Abstract
The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation of reassortant H5 strains with novel gene constellations. A newly emerged HPAI A(H5N8) virus caused poultry outbreaks in the Republic of Korea in 2014. Because newly emerging high-pathogenicity H5 viruses continue to pose public health risks, it is imperative that their pathobiological properties be examined. Here, we characterized A/mallard duck/Korea/W452/2014 (MDk/W452(H5N8)), a representative virus, and evaluated its pathogenic and pandemic potential in various animal models. We found that MDk/W452(H5N8), which originated from the reassortment of wild bird viruses harbored by migratory waterfowl in eastern China, replicated systemically and was lethal in chickens, but appeared to be attenuated, albeit efficiently transmitted, in ducks. Despite predominant attachment to avian-like virus receptors, MDk/W452(H5N8) also exhibited detectable human virus-like receptor binding and replicated in human respiratory tract tissues. In mice, MDk/W452(H5N8) was moderately pathogenic and had limited tissue tropism relative to previous HPAI A(H5N1) viruses. It also induced moderate nasal wash titers in inoculated ferrets; additionally, it was recovered in extrapulmonary tissues and one of three direct-contact ferrets seroconverted without shedding. Moreover, domesticated cats appeared to be more susceptible than dogs to virus infection. With their potential to become established in ducks, continued circulation of A(H5N8) viruses could alter the genetic evolution of pre-existing avian poultry strains. Overall, detailed virological investigation remains a necessity given the capacity of H5 viruses to evolve to cause human illness with few changes in the viral genome.
Keyword
avian influenza virusgenetic evolutionHPAI A(H5N8)migratory waterfowlreassortment
ISSN
2222-1751
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1038/emi.2014.75
Type
Article
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1. Journal Articles > Journal Articles
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