Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging = 유전체 분석을 통한 노화에 따른 근육의 microRNA-mRNA 네트워크 규명

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dc.contributor.authorJi Young Kim-
dc.contributor.authorYoung Kyu Park-
dc.contributor.authorKwang-Pyo Lee-
dc.contributor.authorSeung Min Lee-
dc.contributor.authorTae-Wook Kang-
dc.contributor.authorHee Jin Kim-
dc.contributor.authorSo Hee Dho-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorKi Sun Kwon-
dc.date.accessioned2017-04-19T09:57:42Z-
dc.date.available2017-04-19T09:57:42Z-
dc.date.issued2014-
dc.identifier.issn1945-4589-
dc.identifier.uri10.18632/aging.100677ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12235-
dc.description.abstractSkeletal muscle degenerates progressively, losing mass (sarcopenia) over time, which leads to reduced physical ability and often results in secondary diseases such as diabetes and obesity. The regulation of gene expression by microRNAs is a key event in muscle development and disease. To understand genome-wide changes in microRNAs and mRNAs during muscle aging, we sequenced microRNAs and mRNAs from mouse gastrocnemius muscles at two different ages (6 and 24 months). Thirty-four microRNAs (15 up-regulated and 19 down-regulated) were differentially expressed with age, including the microRNAs miR-206 and -434, which were differentially expressed in aged muscle in previous studies. Interestingly, eight microRNAs in a microRNA cluster at the imprinted Dlk1-Dio3 locus on chromosome 12 were coordinately down-regulated. In addition, sixteen novel microRNAs were identified. Integrative analysis of microRNA and mRNA expression revealed that microRNAs may contribute to muscle aging through the positive regulation of transcription, metabolic processes, and kinase activity. Many of the age-related microRNAs have been implicated in human muscular diseases. We suggest that genome-wide microRNA profiling will expand our knowledge of microRNA function in the muscle aging process.-
dc.publisherImpact Journals Llc-
dc.titleGenome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging = 유전체 분석을 통한 노화에 따른 근육의 microRNA-mRNA 네트워크 규명-
dc.title.alternativeGenome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging-
dc.typeArticle-
dc.citation.titleAging-Us-
dc.citation.number7-
dc.citation.endPage544-
dc.citation.startPage524-
dc.citation.volume6-
dc.contributor.affiliatedAuthorJi Young Kim-
dc.contributor.affiliatedAuthorYoung Kyu Park-
dc.contributor.affiliatedAuthorKwang-Pyo Lee-
dc.contributor.affiliatedAuthorSeung Min Lee-
dc.contributor.affiliatedAuthorTae-Wook Kang-
dc.contributor.affiliatedAuthorHee Jin Kim-
dc.contributor.affiliatedAuthorSo Hee Dho-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.alternativeName김지영-
dc.contributor.alternativeName박영규-
dc.contributor.alternativeName이광표-
dc.contributor.alternativeName이승민-
dc.contributor.alternativeName강태욱-
dc.contributor.alternativeName김희진-
dc.contributor.alternativeName도소희-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName권기선-
dc.identifier.bibliographicCitationAging-Us, vol. 6, no. 7, pp. 524-544-
dc.identifier.doi10.18632/aging.100677-
dc.subject.keywordAging-
dc.subject.keywordImprinted Dlk1-Dio3-
dc.subject.keywordMicroRNA cluster-
dc.subject.keywordMicroRNA profiling-
dc.subject.keywordNovel microRNA-
dc.subject.keywordSkeletal muscle-
dc.subject.localAging-
dc.subject.localaging-
dc.subject.localImprinted Dlk1-Dio3-
dc.subject.localMicroRNA cluster-
dc.subject.localMicroRNA profiling-
dc.subject.localNovel microRNA-
dc.subject.localskeletal muscle-
dc.subject.localSkeletal muscle-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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