Melatonin prevents gentamicin-induced testicular toxicity and oxidative stress in rats

Cited 19 time in scopus
Metadata Downloads
Title
Melatonin prevents gentamicin-induced testicular toxicity and oxidative stress in rats
Author(s)
S H Kim; In Chul Lee; H S Baek; In Sik Shin; C Moon; S H Kim; Woon Kee YoonKi Hoan NamHyoung-Chin Kim; J C Kim
Bibliographic Citation
Andrologia, vol. 46, no. 9, pp. 1032-1040
Publication Year
2014
Abstract
Summary: This study investigated the protective effects of melatonin (MT) against gentamicin (GM)-induced testicular toxicity and oxidative damage in rats. GM (100 mg kg-1) was injected intraperitoneally (i.p.) to rats for 6 days. MT (15 mg kg-1) was administered i.p. to rats for 6 days at 1 hr after the GM treatment. GM caused a decrease in prostate and seminal vesicle weights, sperm count and sperm motility. Histopathological examination showed various morphological alterations in the testis, characterised by degeneration of spermatogonia/spermatocytes, decrease in the number of early spermatogenic cells and vacuolisation. In addition, an increased malondialdehyde concentration and decreased glutathione content and glutathione reductase, catalase and glutathione-S-transferase activities were found in the testis. In contrast, MT treatment significantly attenuated the testicular toxicity of GM, including decreased reproductive organ weights, sperm count, and sperm motility and increased histopathological alterations. MT also had an antioxidant benefit by decreasing the lipid peroxidative product malondialdehyde and increasing the level of the antioxidant glutathione and the activities of antioxidant enzymes in the testis. These results indicate that MT prevents testicular toxicity induced by GM in rats, presumably due to its potent antioxidant activity, and its ability to inhibit lipid peroxidation, and restore antioxidant enzyme activity.
Keyword
GentamicinMelatoninOxidative stressProtectionTesticular toxicity
ISSN
0303-4569
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/and.12191
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.