Genome-wide analysis of DNA methylation patterns in horse

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dc.contributor.authorJ R Lee-
dc.contributor.authorC P Hong-
dc.contributor.authorJ W Moon-
dc.contributor.authorY D Jung-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorT H Kim-
dc.contributor.authorJ A Gim-
dc.contributor.authorJ H Bae-
dc.contributor.authorY Choi-
dc.contributor.authorJ Eo-
dc.contributor.authorY J Kwon-
dc.contributor.authorS Song-
dc.contributor.authorJ Ko-
dc.contributor.authorY M Yang-
dc.contributor.authorH K Lee-
dc.contributor.authorK D Park-
dc.contributor.authorK Ahn-
dc.contributor.authorK T Do-
dc.contributor.authorH S Ha-
dc.contributor.authorK Han-
dc.contributor.authorJ M Yi-
dc.contributor.authorH J Cha-
dc.contributor.authorB W Cho-
dc.contributor.authorJ Bhak-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:57:50Z-
dc.date.available2017-04-19T09:57:50Z-
dc.date.issued2014-
dc.identifier.issn1471-2164-
dc.identifier.uri10.1186/1471-2164-15-598ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12243-
dc.description.abstractBackground: DNA methylation is an epigenetic regulatory mechanism that plays an essential role in mediating biological processes and determining phenotypic plasticity in organisms. Although the horse reference genome and whole transcriptome data are publically available the global DNA methylation data are yet to be known.Results: We report the first genome-wide DNA methylation characteristics data from skeletal muscle, heart, lung, and cerebrum tissues of thoroughbred (TH) and Jeju (JH) horses, an indigenous Korea breed, respectively by methyl-DNA immunoprecipitation sequencing. The analysis of the DNA methylation patterns indicated that the average methylation density was the lowest in the promoter region, while the density in the coding DNA sequence region was the highest. Among repeat elements, a relatively high density of methylation was observed in long interspersed nuclear elements compared to short interspersed nuclear elements or long terminal repeat elements. We also successfully identified differential methylated regions through a comparative analysis of corresponding tissues from TH and JH, indicating that the gene body regions showed a high methylation density.Conclusions: We provide report the first DNA methylation landscape and differentially methylated genomic regions (DMRs) of thoroughbred and Jeju horses, providing comprehensive DMRs maps of the DNA methylome. These data are invaluable resource to better understanding of epigenetics in the horse providing information for the further biological function analyses.-
dc.publisherSpringer-BMC-
dc.titleGenome-wide analysis of DNA methylation patterns in horse-
dc.title.alternativeGenome-wide analysis of DNA methylation patterns in horse-
dc.typeArticle-
dc.citation.titleBMC Genomics-
dc.citation.number0-
dc.citation.endPage598-
dc.citation.startPage598-
dc.citation.volume15-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.alternativeName이자랑-
dc.contributor.alternativeName홍찬표-
dc.contributor.alternativeName문재우-
dc.contributor.alternativeName정이든-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName김태형-
dc.contributor.alternativeName김정안-
dc.contributor.alternativeName배진한-
dc.contributor.alternativeName최유리-
dc.contributor.alternativeName어정우-
dc.contributor.alternativeName권윤정-
dc.contributor.alternativeName송상훈-
dc.contributor.alternativeName고준수-
dc.contributor.alternativeName양영목-
dc.contributor.alternativeName이학교-
dc.contributor.alternativeName박경도-
dc.contributor.alternativeName안궁-
dc.contributor.alternativeName도경탁-
dc.contributor.alternativeName하홍석-
dc.contributor.alternativeName한규동-
dc.contributor.alternativeName이주미-
dc.contributor.alternativeName차희재-
dc.contributor.alternativeName조병욱-
dc.contributor.alternativeName박종화-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationBMC Genomics, vol. 15, pp. 598-598-
dc.identifier.doi10.1186/1471-2164-15-598-
dc.subject.keywordDifferential methylated region (DMR)-
dc.subject.keywordGenome-wide DNA methylation-
dc.subject.keywordJeju horse-
dc.subject.keywordMeDIP-seq-
dc.subject.keywordThoroughbred horse-
dc.subject.localDifferential methylated region (DMR)-
dc.subject.localGenome-wide DNA methylation-
dc.subject.localJeju horse-
dc.subject.localMeDIP-seq-
dc.subject.localMeDIP-Seq-
dc.subject.localThoroughbred horse-
dc.description.journalClassY-
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