APPEX: analysis platform for the identification of prognostic gene expression signatures in cancer

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dc.contributor.authorSeon-Kyu Kim-
dc.contributor.authorJong Hwan Kim-
dc.contributor.authorS J Yoon-
dc.contributor.authorW J Kim-
dc.contributor.authorSeon-Young Kim-
dc.date.accessioned2017-04-19T09:57:54Z-
dc.date.available2017-04-19T09:57:54Z-
dc.date.issued2014-
dc.identifier.issn1367-4803-
dc.identifier.uri10.1093/bioinformatics/btu521ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12255-
dc.description.abstractBecause cancer has heterogeneous clinical behaviors due to the progressive accumulation of multiple genetic and epigenetic alterations, the identification of robust molecular signatures for predicting cancer outcome is profoundly important. Here, we introduce the APPEX Web-based analysis platform as a versatile tool for identifying prognostic molecular signatures that predict cancer diversity. We incorporated most of statistical methods for survival analysis and implemented seven survival analysis workflows, including CoxSingle, CoxMulti, IntransSingle, IntransMulti, SuperPC, TimeRoc and multivariate. A total of 236 publicly available datasets were collected, processed and stored to support easy independent validation of prognostic signatures. Two case studies including disease recurrence and bladder cancer progression were described using different combinations of the seven workflows.-
dc.publisherOxford Univ Press-
dc.titleAPPEX: analysis platform for the identification of prognostic gene expression signatures in cancer-
dc.title.alternativeAPPEX: analysis platform for the identification of prognostic gene expression signatures in cancer-
dc.typeArticle-
dc.citation.titleBioinformatics-
dc.citation.number22-
dc.citation.endPage3286-
dc.citation.startPage3284-
dc.citation.volume30-
dc.contributor.affiliatedAuthorSeon-Kyu Kim-
dc.contributor.affiliatedAuthorJong Hwan Kim-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.alternativeName김선규-
dc.contributor.alternativeName김종환-
dc.contributor.alternativeName윤석중-
dc.contributor.alternativeName김원재-
dc.contributor.alternativeName김선영-
dc.identifier.bibliographicCitationBioinformatics, vol. 30, no. 22, pp. 3284-3286-
dc.identifier.doi10.1093/bioinformatics/btu521-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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