Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation

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dc.contributor.authorH J Park-
dc.contributor.authorS Y Kim-
dc.contributor.authorN Y Song-
dc.contributor.authorJ G Cho-
dc.contributor.authorJi Hyun Kang-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorD Y Lee-
dc.contributor.authorG S Kim-
dc.contributor.authorY B Kim-
dc.contributor.authorH C Kang-
dc.contributor.authorN I Baek-
dc.date.accessioned2017-04-19T09:58:13Z-
dc.date.available2017-04-19T09:58:13Z-
dc.date.issued2014-
dc.identifier.issn02536269-
dc.identifier.uri10.1007/s12272-013-0304-2ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12273-
dc.description.abstractThe stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively.-
dc.publisherPharmaceutical Soc Korea-
dc.titleProcyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation-
dc.title.alternativeProcyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage1410-
dc.citation.startPage1403-
dc.citation.volume37-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName박희정-
dc.contributor.alternativeName김수연-
dc.contributor.alternativeName송나영-
dc.contributor.alternativeName조진경-
dc.contributor.alternativeName강지현-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이대영-
dc.contributor.alternativeName김금숙-
dc.contributor.alternativeName김용범-
dc.contributor.alternativeName강희철-
dc.contributor.alternativeName백남인-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 37, no. 11, pp. 1403-1410-
dc.identifier.doi10.1007/s12272-013-0304-2-
dc.subject.keywordLow-density lipoprotein-
dc.subject.keywordMachilus japonica-
dc.subject.keywordProcyanidin-
dc.subject.localLow-density lipoprotein-
dc.subject.localMachilus japonica-
dc.subject.localProcyanidin-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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