Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice = 테로카판 고함유 콩잎 추출물의 제2형 당뇨모델 마우스에서 인슐린 민감성과 췌장 베타세포 증식을 개선하는 효능

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dc.contributor.authorUn Hee Kim-
dc.contributor.authorJeong Hyun Yoon-
dc.contributor.authorHua Li-
dc.contributor.authorJi Hyun Kang-
dc.contributor.authorHyeon Seon Ji-
dc.contributor.authorK H Park-
dc.contributor.authorD H Shin-
dc.contributor.authorHo Yong Park-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2017-04-19T09:58:38Z-
dc.date.available2017-04-19T09:58:38Z-
dc.date.issued2014-
dc.identifier.issn1420-3049-
dc.identifier.uri10.3390/molecules191118493ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12277-
dc.description.abstractIn Korea, soy (Glycine max (L.) Merr.) leaves are eaten as a seasonal vegetable or pickled in soy sauce. Ethyl acetate extracts of soy leaves (EASL) are enriched in pterocarpans and have potent α-glucosidase inhibitory activity. This study investigated the molecular mechanisms underlying the anti-diabetic effect of EASL in C57BL/6J mice with high-fat diet (HFD)-induced type 2 diabetes. Mice were randomly divided into normal diet (ND), HFD (60 kcal% fat diet), EASL (HFD with 0.56% (wt/wt) EASL), and Pinitol (HFD with 0.15% (wt/wt) pinitol) groups. Weight gain and abdominal fat accumulation were significantly suppressed by EASL. Levels of plasma glucose, HbA1c, and insulin in the EASL group were significantly lower than those of the HFD group, and the pancreatic islet of the EASL group had greater size than those of the HFD group. EASL group up-regulated neurogenin 3 (Ngn3), paired box 4 (Pax4), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which are markers of pancreatic cell development, as well as insulin receptor substrate 1 (IRS1), IRS2, and glucose transporter 4 (GLUT4), which are related to insulin sensitivity. Furthermore, EASL suppressed genes involved in hepatic gluconeogenesis and steatosis. These results suggest that EASL improves plasma glucose and insulin levels in mice with HDF-induced type 2 diabetes by regulating β-cell proliferation and insulin sensitivity.-
dc.publisherMDPI-
dc.titlePterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice = 테로카판 고함유 콩잎 추출물의 제2형 당뇨모델 마우스에서 인슐린 민감성과 췌장 베타세포 증식을 개선하는 효능-
dc.title.alternativePterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number11-
dc.citation.endPage18510-
dc.citation.startPage18493-
dc.citation.volume19-
dc.contributor.affiliatedAuthorUn Hee Kim-
dc.contributor.affiliatedAuthorJeong Hyun Yoon-
dc.contributor.affiliatedAuthorHua Li-
dc.contributor.affiliatedAuthorJi Hyun Kang-
dc.contributor.affiliatedAuthorHyeon Seon Ji-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName김언희-
dc.contributor.alternativeName윤정현-
dc.contributor.alternativeName이화-
dc.contributor.alternativeName강지현-
dc.contributor.alternativeName지현선-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName신동하-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationMolecules, vol. 19, no. 11, pp. 18493-18510-
dc.identifier.doi10.3390/molecules191118493-
dc.subject.keywordGlycine max-
dc.subject.keywordInsulin sensitivity-
dc.subject.keywordPancreas-
dc.subject.keywordPterocarpans-
dc.subject.keywordType 2 diabetes-
dc.subject.localglycine max-
dc.subject.localGlycine max-
dc.subject.localinsulin sensitivity-
dc.subject.localInsulin sensitivity-
dc.subject.localpancreas-
dc.subject.localPancreas-
dc.subject.localPterocarpan-
dc.subject.localPterocarpans-
dc.subject.localpterocarpan-
dc.subject.localType 2 diabetes-
dc.subject.localType 2 Diabetes-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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