Structural insights into the transcription-independent apoptotic pathway of p53 = p53 의 전사 독립적인 세포사멸 경로에 관한 구조적 이해

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Title
Structural insights into the transcription-independent apoptotic pathway of p53 = p53 의 전사 독립적인 세포사멸 경로에 관한 구조적 이해
Author(s)
Seung-Wook Chi
Bibliographic Citation
BMB Reports, vol. 47, no. 3, pp. 167-172
Publication Year
2014
Abstract
Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcriptionindependent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcriptionindependent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.
Keyword
Anticancer therapyApoptosisBcl-2 family proteinsp53Structure
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2014.47.3.261
Type
Article
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
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