Dual pH-sensitive oxidative stress generating micellar nanoparticles as a novel anticancer therapeutic agent

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dc.contributor.authorS Park-
dc.contributor.authorB Kwon-
dc.contributor.authorW Yang-
dc.contributor.authorE Han-
dc.contributor.authorW Yoo-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorD Lee-
dc.date.accessioned2017-04-19T09:59:23Z-
dc.date.available2017-04-19T09:59:23Z-
dc.date.issued2014-
dc.identifier.issn0168-3659-
dc.identifier.uri10.1016/j.jconrel.2014.09.017ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12315-
dc.description.abstractCancer cells are under oxidative stress due to a large production of reactive oxygen species (ROS), which involve in cell proliferation and cancer promotion and progression. On the other hand, ROS promotes cell death, depending on the rate of ROS production and the activity of antioxidant systems. Recently, "oxidation therapy" has arisen as a promising anticancer strategy, which can be achieved by inducing the generation of cytotoxic level of ROS or inhibiting the antioxidant systems in tumor cells. Here, we report oxidative stress amplifying nanoplatforms as novel anticancer therapeutics, which are able not only to suppress antioxidant but also to generate ROS simultaneously in acidic tumor microenvironments. The oxidative stress amplifying nanoplatforms are composed of dual pH-sensitive PBCAE copolymer, polymeric prodrug of BCA (benzoyloxycinnamaldehyde) and heme oxygenase-1 (HO-1) inhibiting zinc protoporphyrin (ZnPP). PBCAE was designed to incorporate ROS-generating BCA in its backbone via acid-cleavable acetal linkages and self-assemble to form micelles that encapsulate ZnPP. In vitro proof-of-concept studies revealed that ZnPP encapsulated in PBCAE micelles suppressed HO-1 to make cancer cells more vulnerable to BCA-induced ROS, leading to enhanced apoptotic cell death. In addition, ZnPP-loaded PBCAE micelles significantly suppressed the tumor growth in human cancer xenograft mouse models. We believe that oxidative stress amplifying micellar nanoparticles have a great potential as novel redox anticancer therapeutics.-
dc.publisherElsevier-
dc.titleDual pH-sensitive oxidative stress generating micellar nanoparticles as a novel anticancer therapeutic agent-
dc.title.alternativeDual pH-sensitive oxidative stress generating micellar nanoparticles as a novel anticancer therapeutic agent-
dc.typeArticle-
dc.citation.titleJournal of Controlled Release-
dc.citation.number0-
dc.citation.endPage27-
dc.citation.startPage19-
dc.citation.volume196-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName박상아-
dc.contributor.alternativeName권병수-
dc.contributor.alternativeName양원석-
dc.contributor.alternativeName한은지-
dc.contributor.alternativeName유우영-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName이동원-
dc.identifier.bibliographicCitationJournal of Controlled Release, vol. 196, pp. 19-27-
dc.identifier.doi10.1016/j.jconrel.2014.09.017-
dc.subject.keywordApoptosis-
dc.subject.keywordCancer-
dc.subject.keywordMicelles-
dc.subject.keywordOxidative stress-
dc.subject.keywordReactive oxygen species-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localCancers-
dc.subject.localcancer-
dc.subject.localCancer-
dc.subject.localMicelles-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localReactive oxidative species-
dc.subject.localReactive oxygen species(ROS)-
dc.subject.localReactive oxygen species-
dc.subject.localReactive Oxygen Species (ROS)-
dc.subject.localReactive Oxygen Species-
dc.subject.localROS-
dc.subject.localReactive oxygen species (ROS)-
dc.subject.localreactive oxygen species-
dc.subject.localreactive oxygen species (ROS)-
dc.description.journalClassY-
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