Melatonin reduces airway inflammation in ovalbumin-induced asthma = 난백알부민으로 유도된 천식에서 멜라토닌의 기도염증 완화

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Title
Melatonin reduces airway inflammation in ovalbumin-induced asthma = 난백알부민으로 유도된 천식에서 멜라토닌의 기도염증 완화
Author(s)
In Sik Shin; Ji Won Park; Na Rae Shin; Chan Mi Jeon; Ok-Kyoung Kwon; J S Kim; J C Kim; Sei-Ryang OhKyung Seop Ahn
Bibliographic Citation
Immunobiology, vol. 219, no. 12, pp. 901-908
Publication Year
2014
Abstract
Asthma is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of melatonin on allergic asthma using a murine model of ovalbumin (OVA)-induced allergic asthma and BEAS-2B cells. To induce allergic asthma, the mice were sensitized and airway-challenged with OVA. Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15. mg/kg from days 21 to 23 after the initial OVA sensitization. We investigated the effects of melatonin on proinflammatory cytokines and matrix metalloproteinase-9 (MMP-9) activity and expression in tumor necrosis factor (TNF)-α-stimulated BEAS-2B cells. The administration of melatonin significantly decreased the number of inflammatory cells, airway hyperresponsiveness, and immunoglobulin (Ig) E with reductions in interleukin (IL)-4, IL-5, and IL-13. Melatonin attenuated the airway inflammation and the mucus production in lung tissue and significantly suppressed elevated MMP-9 expression and activity induced by an OVA challenge. In TNF-α-stimulated BEAS-2B cells, treatment with melatonin significantly reduced the levels of proinflammatory cytokines and lowered the expression and activity of MMP-9. These results indicate that melatonin effectively suppressed allergic asthma induced by an OVA challenge. The results suggest a potential role for melatonin in treating asthma.
ISSN
0171-2985
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imbio.2014.08.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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