Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | M J Jang | - |
| dc.contributor.author | Ye Sol Kim | - |
| dc.contributor.author | E Y Bae | - |
| dc.contributor.author | T S Oh | - |
| dc.contributor.author | H J Choi | - |
| dc.contributor.author | J H Lee | - |
| dc.contributor.author | Hyun-Mee Oh | - |
| dc.contributor.author | Seung Woong Lee | - |
| dc.date.accessioned | 2017-04-19T10:00:21Z | - |
| dc.date.available | 2017-04-19T10:00:21Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.issn | 1420-3049 | - |
| dc.identifier.uri | 10.3390/molecules191220340 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12348 | - |
| dc.description.abstract | Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D ( 3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 μM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation. | - |
| dc.publisher | MDPI | - |
| dc.title | Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion | - |
| dc.title.alternative | Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion | - |
| dc.type | Article | - |
| dc.citation.title | Molecules | - |
| dc.citation.number | 12 | - |
| dc.citation.endPage | 20349 | - |
| dc.citation.startPage | 20340 | - |
| dc.citation.volume | 19 | - |
| dc.contributor.affiliatedAuthor | Ye Sol Kim | - |
| dc.contributor.affiliatedAuthor | Hyun-Mee Oh | - |
| dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
| dc.contributor.alternativeName | 장명준 | - |
| dc.contributor.alternativeName | 김예솔 | - |
| dc.contributor.alternativeName | 배은영 | - |
| dc.contributor.alternativeName | 오태석 | - |
| dc.contributor.alternativeName | 최화정 | - |
| dc.contributor.alternativeName | 이정희 | - |
| dc.contributor.alternativeName | 오현미 | - |
| dc.contributor.alternativeName | 이승웅 | - |
| dc.identifier.bibliographicCitation | Molecules, vol. 19, no. 12, pp. 20340-20349 | - |
| dc.identifier.doi | 10.3390/molecules191220340 | - |
| dc.subject.keyword | Anti-inflammatory agents | - |
| dc.subject.keyword | Bupleurum falcatum l | - |
| dc.subject.keyword | Cell adhesion molecules | - |
| dc.subject.keyword | Saikosaponin | - |
| dc.subject.keyword | Selectin | - |
| dc.subject.keyword | Triterpenoid saponin | - |
| dc.subject.local | Anti-inflammatory agents | - |
| dc.subject.local | anti-inflammatory agent | - |
| dc.subject.local | Bupleurum falcatum L | - |
| dc.subject.local | Bupleurum falcatum l | - |
| dc.subject.local | Cell adhesion molecule | - |
| dc.subject.local | cell adhesion molecule | - |
| dc.subject.local | Cell adhesion molecules | - |
| dc.subject.local | Saikosaponins | - |
| dc.subject.local | Saikosaponin | - |
| dc.subject.local | Selectin | - |
| dc.subject.local | selectin | - |
| dc.subject.local | triterpenoid saponin | - |
| dc.subject.local | Triterpenoid saponin | - |
| dc.subject.local | Triterpenoid saponins | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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