Betaine supplementation improves beneficial effects of boxthorn (Lycium chinense Mill.) leaf on body weight/body fat increase and plasma/liver triglycerides accumulation in high-fat diet-fed C57BL/6 mice

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Title
Betaine supplementation improves beneficial effects of boxthorn (Lycium chinense Mill.) leaf on body weight/body fat increase and plasma/liver triglycerides accumulation in high-fat diet-fed C57BL/6 mice
Author(s)
Moo Rim Kang; Chang Woo Lee; Ik Jun Cho; Myeong Youl Lee; Jung Hyu Shin; Soo Jin Oh; Ji Eun Yun; Woon Kee Yoon; S B Han; E E Kim; S H Bok; Jong Soon Kang
Bibliographic Citation
Journal of Food Biochemistry, vol. 38, no. 6, pp. 620-626
Publication Year
2014
Abstract
In the present study, we investigated the combinatorial effects of betaine supplementation and boxthorn (Lycium chinenseMill.) leaf on high-fat diet (HFD)-induced body weight/body fat increase, plasma lipid profile and liver damage. Suboptimal dosage of hot water extract of boxthorn leaf (Lycium chinense water extract, LWE) exerted partial inhibitory effect on body weight/body fat increase in HFD-fed mice. Betaine supplementation potentiated the effect of LWE showing a significant inhibition against HFD-induced increase in body weight/body fat. However, both LWE alone and LWE plus betaine had no effect on plasma cholesterols, including total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in HFD-fed mice. In contrast, HFD-induced increases in plasma and liver triglycerides were partially suppressed by LWE treatment and this was potentiated by betaine supplementation. In addition, both LWE alone and LWE plus betaine significantly suppressed HFD-induced glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase. Collectively, our results suggest that the combination of boxthorn leaf and betaine might be beneficial for the management of obesity and nonalcoholic fatty liver disease.
ISSN
0145-8884
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/jfbc.12099
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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