Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity

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dc.contributor.authorA Primikyri-
dc.contributor.authorM V Chatziathanasiadou-
dc.contributor.authorE Karali-
dc.contributor.authorE Kostaras-
dc.contributor.authorM D Mantzaris-
dc.contributor.authorE Hatzimichael-
dc.contributor.authorShin Jae-Sun-
dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorE Briasoulis-
dc.contributor.authorE Kolettas-
dc.contributor.authorI P Gerothanassis-
dc.contributor.authorA G Tzakos-
dc.date.accessioned2017-04-19T10:00:34Z-
dc.date.available2017-04-19T10:00:34Z-
dc.date.issued2014-
dc.identifier.issn1554-8929-
dc.identifier.uri10.1021/cb500259eko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12364-
dc.description.abstractBcl-2 family proteins are important regulators of apoptosis and its antiapoptotic members, which are overexpressed in many types of cancer, are of high prognostic significance, establishing them as attractive therapeutic targets. Quercetin, a natural flavonoid, has drawn much attention because it exerts anticancer effects, while sparing normal cells. A multidisciplinary approach has been employed herein, in an effort to reveal its mode of action including dose-response antiproliferative activity and induced apoptosis effect, biochemical and physicochemical assays, and computational calculations. It may be concluded that, quercetin binds directly to the BH3 domain of Bcl-2 and Bcl-xL proteins, thereby inhibiting their activity and promoting cancer cell apoptosis.-
dc.publisherAmer Chem Soc-
dc.titleDirect binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity-
dc.title.alternativeDirect binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity-
dc.typeArticle-
dc.citation.titleACS Chemical Biology-
dc.citation.number0-
dc.citation.endPage2741-
dc.citation.startPage2737-
dc.citation.volume9-
dc.contributor.affiliatedAuthorShin Jae-Sun-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.alternativeNamePrimikyri-
dc.contributor.alternativeNameChatziathanasia-
dc.contributor.alternativeNameKarali-
dc.contributor.alternativeNameKostaras-
dc.contributor.alternativeNameMantzaris-
dc.contributor.alternativeNameHatzimichael-
dc.contributor.alternativeName신재선-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeNameBriasoulis-
dc.contributor.alternativeNameKolettas-
dc.contributor.alternativeNameGerothanassis-
dc.contributor.alternativeNameTzakos-
dc.identifier.bibliographicCitationACS Chemical Biology, vol. 9, pp. 2737-2741-
dc.identifier.doi10.1021/cb500259e-
dc.description.journalClassY-
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Division of Biomedical Research > 1. Journal Articles
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