Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage

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Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage
N Y Sung; E B Byun; D S Song; Yeung Bae Jin; J N Park; J K Kim; J H Park; B S Song; S H Park; J W Lee; J H Kim
Bibliographic Citation
Radiation Physics and Chemistry, vol. 105, pp. 17-21
Publication Year
This present study was to examine the cytotoxicity and anti-inflammatory activity of gamma (γ)-irradiated genistein in murine peritoneal macrophage. Inflammation to macrophage was induced by adding the lipopolysaccharide (LPS). γ-Irradiated genistein significantly decreased the cytotoxicity to murine peritoneal macrophage in dose ranges from 5 to 10. μM than that of non-irradiated genistein. Anti-inflammatory activity within the doses less than 2. μM showed that γ-irradiated genistein treatment remarkably reduced the lipopolysaccharide-induced inflammation by decreasing the nitric oxide (NO) and cytokines (TNF-α, IL-6) production. In a structural analysis through the high pressure liquid chromatography (HPLC), γ-irradiated genistein showed a new peak production distinguished from main peak of genistein (non-irradiated). Therefore, increase of anti-inflammatory activity may closely mediate with structural changes induced by γ irradiation exposure. Based on the above result, γ-irradiation could be an effective tool for reduction of toxicity and increase of physiological activity of biomolecules.
Anti-inflammatory activityCytokineCytotoxicityGamma irradiationGenistein
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Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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