Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage

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dc.contributor.authorN Y Sung-
dc.contributor.authorE B Byun-
dc.contributor.authorD S Song-
dc.contributor.authorYeung Bae Jin-
dc.contributor.authorJ N Park-
dc.contributor.authorJ K Kim-
dc.contributor.authorJ H Park-
dc.contributor.authorB S Song-
dc.contributor.authorS H Park-
dc.contributor.authorJ W Lee-
dc.contributor.authorJ H Kim-
dc.date.accessioned2017-04-19T10:00:34Z-
dc.date.available2017-04-19T10:00:34Z-
dc.date.issued2014-
dc.identifier.issn0969-806X-
dc.identifier.uri10.1016/j.radphyschem.2014.05.029ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12367-
dc.description.abstractThis present study was to examine the cytotoxicity and anti-inflammatory activity of gamma (γ)-irradiated genistein in murine peritoneal macrophage. Inflammation to macrophage was induced by adding the lipopolysaccharide (LPS). γ-Irradiated genistein significantly decreased the cytotoxicity to murine peritoneal macrophage in dose ranges from 5 to 10. μM than that of non-irradiated genistein. Anti-inflammatory activity within the doses less than 2. μM showed that γ-irradiated genistein treatment remarkably reduced the lipopolysaccharide-induced inflammation by decreasing the nitric oxide (NO) and cytokines (TNF-α, IL-6) production. In a structural analysis through the high pressure liquid chromatography (HPLC), γ-irradiated genistein showed a new peak production distinguished from main peak of genistein (non-irradiated). Therefore, increase of anti-inflammatory activity may closely mediate with structural changes induced by γ irradiation exposure. Based on the above result, γ-irradiation could be an effective tool for reduction of toxicity and increase of physiological activity of biomolecules.-
dc.publisherElsevier-
dc.titleAnti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage-
dc.title.alternativeAnti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage-
dc.typeArticle-
dc.citation.titleRadiation Physics and Chemistry-
dc.citation.number0-
dc.citation.endPage21-
dc.citation.startPage17-
dc.citation.volume105-
dc.contributor.affiliatedAuthorYeung Bae Jin-
dc.contributor.alternativeName성낙윤-
dc.contributor.alternativeName변의백-
dc.contributor.alternativeName송두섭-
dc.contributor.alternativeName진영배-
dc.contributor.alternativeName박재남-
dc.contributor.alternativeName김재경-
dc.contributor.alternativeName박종흠-
dc.contributor.alternativeName송범석-
dc.contributor.alternativeName박상현-
dc.contributor.alternativeName이주운-
dc.contributor.alternativeName김재훈-
dc.identifier.bibliographicCitationRadiation Physics and Chemistry, vol. 105, pp. 17-21-
dc.identifier.doi10.1016/j.radphyschem.2014.05.029-
dc.subject.keywordAnti-inflammatory activity-
dc.subject.keywordCytokine-
dc.subject.keywordCytotoxicity-
dc.subject.keywordGamma irradiation-
dc.subject.keywordGenistein-
dc.subject.localAnti-inflammatory activity-
dc.subject.localAnti-infl ammatory activity-
dc.subject.localanti-inflammatory activity-
dc.subject.localAnti-inflammatory activities-
dc.subject.localcytokine-
dc.subject.localCytokines-
dc.subject.localCytokine-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.subject.localGamma irradiation-
dc.subject.localgamma irradiation-
dc.subject.localgenistein-
dc.subject.localGenistein-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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