DC Field | Value | Language |
---|---|---|
dc.contributor.author | N Y Sung | - |
dc.contributor.author | E B Byun | - |
dc.contributor.author | D S Song | - |
dc.contributor.author | Yeung Bae Jin | - |
dc.contributor.author | J N Park | - |
dc.contributor.author | J K Kim | - |
dc.contributor.author | J H Park | - |
dc.contributor.author | B S Song | - |
dc.contributor.author | S H Park | - |
dc.contributor.author | J W Lee | - |
dc.contributor.author | J H Kim | - |
dc.date.accessioned | 2017-04-19T10:00:34Z | - |
dc.date.available | 2017-04-19T10:00:34Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0969-806X | - |
dc.identifier.uri | 10.1016/j.radphyschem.2014.05.029 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12367 | - |
dc.description.abstract | This present study was to examine the cytotoxicity and anti-inflammatory activity of gamma (γ)-irradiated genistein in murine peritoneal macrophage. Inflammation to macrophage was induced by adding the lipopolysaccharide (LPS). γ-Irradiated genistein significantly decreased the cytotoxicity to murine peritoneal macrophage in dose ranges from 5 to 10. μM than that of non-irradiated genistein. Anti-inflammatory activity within the doses less than 2. μM showed that γ-irradiated genistein treatment remarkably reduced the lipopolysaccharide-induced inflammation by decreasing the nitric oxide (NO) and cytokines (TNF-α, IL-6) production. In a structural analysis through the high pressure liquid chromatography (HPLC), γ-irradiated genistein showed a new peak production distinguished from main peak of genistein (non-irradiated). Therefore, increase of anti-inflammatory activity may closely mediate with structural changes induced by γ irradiation exposure. Based on the above result, γ-irradiation could be an effective tool for reduction of toxicity and increase of physiological activity of biomolecules. | - |
dc.publisher | Elsevier | - |
dc.title | Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage | - |
dc.title.alternative | Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage | - |
dc.type | Article | - |
dc.citation.title | Radiation Physics and Chemistry | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 21 | - |
dc.citation.startPage | 17 | - |
dc.citation.volume | 105 | - |
dc.contributor.affiliatedAuthor | Yeung Bae Jin | - |
dc.contributor.alternativeName | 성낙윤 | - |
dc.contributor.alternativeName | 변의백 | - |
dc.contributor.alternativeName | 송두섭 | - |
dc.contributor.alternativeName | 진영배 | - |
dc.contributor.alternativeName | 박재남 | - |
dc.contributor.alternativeName | 김재경 | - |
dc.contributor.alternativeName | 박종흠 | - |
dc.contributor.alternativeName | 송범석 | - |
dc.contributor.alternativeName | 박상현 | - |
dc.contributor.alternativeName | 이주운 | - |
dc.contributor.alternativeName | 김재훈 | - |
dc.identifier.bibliographicCitation | Radiation Physics and Chemistry, vol. 105, pp. 17-21 | - |
dc.identifier.doi | 10.1016/j.radphyschem.2014.05.029 | - |
dc.subject.keyword | Anti-inflammatory activity | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | Cytotoxicity | - |
dc.subject.keyword | Gamma irradiation | - |
dc.subject.keyword | Genistein | - |
dc.subject.local | Anti-inflammatory activity | - |
dc.subject.local | Anti-infl ammatory activity | - |
dc.subject.local | anti-inflammatory activity | - |
dc.subject.local | Anti-inflammatory activities | - |
dc.subject.local | cytokine | - |
dc.subject.local | Cytokines | - |
dc.subject.local | Cytokine | - |
dc.subject.local | Cytotoxicity | - |
dc.subject.local | cytotoxicity | - |
dc.subject.local | Gamma irradiation | - |
dc.subject.local | gamma irradiation | - |
dc.subject.local | genistein | - |
dc.subject.local | Genistein | - |
dc.description.journalClass | Y | - |
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