Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice = Jaceosidin이 streptozotocin으로 유도된 당뇨 쥐의 혈당강하 및 항산화능에 미치는 영향

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dc.contributor.authorE Park-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorI K Jung-
dc.contributor.authorJ H Kim-
dc.date.accessioned2017-04-19T10:00:35Z-
dc.date.available2017-04-19T10:00:35Z-
dc.date.issued2014-
dc.identifier.issn2288-3886-
dc.identifier.uri10.4163/jnh.2014.47.5.313ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12370-
dc.description.abstractPurpose: In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice. Methods: C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes lowjaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed. Results: Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities. Conclusion: These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleHypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice = Jaceosidin이 streptozotocin으로 유도된 당뇨 쥐의 혈당강하 및 항산화능에 미치는 영향-
dc.title.alternativeHypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice-
dc.typeArticle-
dc.citation.titleJournal of Nutrition and Health-
dc.citation.number5-
dc.citation.endPage320-
dc.citation.startPage313-
dc.citation.volume47-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName박은교-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName정인경-
dc.contributor.alternativeName김정현-
dc.identifier.bibliographicCitationJournal of Nutrition and Health, vol. 47, no. 5, pp. 313-320-
dc.identifier.doi10.4163/jnh.2014.47.5.313-
dc.subject.keywordAntioxidant-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordJaceosidin-
dc.subject.keywordLipid peroxidation-
dc.subject.localAntioxidants-
dc.subject.localantioxidant-
dc.subject.localAnti-oxidant-
dc.subject.localantioxidants-
dc.subject.localANTIOXIDANT-
dc.subject.localanti-oxidants-
dc.subject.localAntioxidant-
dc.subject.localDiabetes mellitus-
dc.subject.localdiabetes mellitus-
dc.subject.localjaceosidin-
dc.subject.localJaceosidin-
dc.subject.localLipid peroxidation-
dc.subject.locallipid peroxidation-
dc.description.journalClassN-
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