Inhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice

Cited 11 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMi Kyung Nam-
dc.contributor.authorHye Ran Choi-
dc.contributor.authorJ S Cho-
dc.contributor.authorSoo Min Cho-
dc.contributor.authorK C Ha-
dc.contributor.authorT H Kim-
dc.contributor.authorHee Young Ryu-
dc.contributor.authorYoung Ik Lee-
dc.date.accessioned2017-04-19T10:00:44Z-
dc.date.available2017-04-19T10:00:44Z-
dc.date.issued2014-
dc.identifier.issn1791-2997-
dc.identifier.uri10.3892/mmr.2014.2398ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12394-
dc.description.abstractThe present study was performed to investigate the potential effects of the unripened dried fruit of Rubus coreanus Miq., Rubi Fructus (RF), on hepatic steatosis and lipid metabolism in mice fed with a high-fat diet (HFD) known to induce obesity and hyperlipidaemia. Rubi Fructus extract (RFex) fed mice demonstrated a reduced body weight and adipose tissue weight. RFex fed mice also demonstrated decreased aminotransferase levels, lipid contents [triglyceride (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C)], leptin content and increased high-density lipoprotein-cholesterol (HDL-C) contents in the plasma. These effects were accompanied by a decreased expression of lipogenic genes, including sterol regulatory element binding protein-1c, liver X receptor, fatty acid synthase (FAS), acetyl-CoA carboxylase, cluster of differentiation 36, lipoprotein lipase and decreased lipogenic enzyme FAS and 3-hydroxy-3 methylglutamyl coenzyme reductase enzyme activities, while elevating carnitine palmitoyltrasferase-1 activity. Based on these results, the present study hypothesized that the inhibitory effect on hepatic steatosis of RFex is the result of the suppression of lipid synthesis in mice fed with HFD, suggesting that RFex may be beneficial in preventing hepatic steatosis and liver lipotoxicity.-
dc.publisherSpandidos Publ Ltd-
dc.titleInhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice-
dc.title.alternativeInhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice-
dc.typeArticle-
dc.citation.titleMolecular Medicine Reports-
dc.citation.number4-
dc.citation.endPage1827-
dc.citation.startPage1821-
dc.citation.volume10-
dc.contributor.affiliatedAuthorMi Kyung Nam-
dc.contributor.affiliatedAuthorHye Ran Choi-
dc.contributor.affiliatedAuthorSoo Min Cho-
dc.contributor.affiliatedAuthorHee Young Ryu-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.alternativeName남미경-
dc.contributor.alternativeName최혜란-
dc.contributor.alternativeName조진숙-
dc.contributor.alternativeName조수민-
dc.contributor.alternativeName하기찬-
dc.contributor.alternativeName김태현-
dc.contributor.alternativeName류희영-
dc.contributor.alternativeName이영익-
dc.identifier.bibliographicCitationMolecular Medicine Reports, vol. 10, no. 4, pp. 1821-1827-
dc.identifier.doi10.3892/mmr.2014.2398-
dc.subject.keywordHepatic steatosis-
dc.subject.keywordHigh-fat diet-
dc.subject.keywordLipogenic enzyme-
dc.subject.keywordLipogenic gene-
dc.subject.keywordLiver lipotoxicity-
dc.subject.keywordRubi fructus-
dc.subject.localHepatic steatosis-
dc.subject.localhepatic steatosis-
dc.subject.localHigh-fat diet-
dc.subject.localhigh-fat diet-
dc.subject.localLipogenic enzyme-
dc.subject.localLipogenic gene-
dc.subject.localLiver lipotoxicity-
dc.subject.localRubi fructus-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.