Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells

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Title
Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells
Author(s)
Ji Eun Yun; Bo Geun Kim; Jong Soon Kang; S K Park; K Lee; D H Hyun; H M Kim; M J In; D C Kim
Bibliographic Citation
Journal of Medicinal Food, vol. 18, no. 1, pp. 102-108
Publication Year
2015
Abstract
This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 μg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.
Keyword
cancer invasionlipid-soluble ginseng extractlung metastasismatrix metalloprotease-2
ISSN
1096-620X
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/jmf.2013.3138
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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