Prognostic significance of catalase expression and its regulatory effects on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas

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dc.contributor.authorM Y Cho-
dc.contributor.authorJ Y Cheong-
dc.contributor.authorW Lim-
dc.contributor.authorS Jo-
dc.contributor.authorY Lee-
dc.contributor.authorH J Wang-
dc.contributor.authorKyou Hoon Han-
dc.contributor.authorH Cho-
dc.date.accessioned2017-04-19T10:00:55Z-
dc.date.available2017-04-19T10:00:55Z-
dc.date.issued2014-
dc.identifier.issn1949-2553-
dc.identifier.uri10.18632/oncotarget.2625ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12411-
dc.description.abstractHepatitis B virus X protein (HBx) plays a role in liver cancer development. We previously showed that ROS increased HBx levels and here, we investigated the role of antioxidants in the regulation of HBx expression and their clinical relevance. We found that overexpression of catalase induced a significant loss in HBx levels. The cysteine null mutant of HBx (Cys-) showed a dramatic reduction in its protein stability. In clonogenic proliferation assays, Huh7-X cells produced a significant number of colonies whereas Huh7-Cys- cells failed to generate them. The Cys at position 69 of HBx was crucial to maintain its protein stability and transactivation function in response to ROS. Among 50 HBV-related hepatocellular carcinoma (HCC) specimens, 72% of HCCs showed lower catalase levels than those of surrounding non-tumor tissues. In advanced stage IV, catalase levels in non-tumor tissues were increased whereas those in tumors were further reduced. Accordingly, patients with a high T/N ratio for catalase showed significantly longer survival than those with a low T/N ratio. Together, catalase expression in HCC patients can be clinically useful for prediction of patient survival, and restoration of catalase expression in HCCs could be an important strategy for intervention in HBV-induced liver diseases.-
dc.publisherImpact Journalsko
dc.titlePrognostic significance of catalase expression and its regulatory effects on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas-
dc.title.alternativePrognostic significance of catalase expression and its regulatory effects on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas-
dc.typeArticle-
dc.citation.titleOncotarget-
dc.citation.number23-
dc.citation.endPage12246-
dc.citation.startPage12233-
dc.citation.volume5-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName조미영-
dc.contributor.alternativeName정재연-
dc.contributor.alternativeName임원충-
dc.contributor.alternativeName조수진-
dc.contributor.alternativeName이영수-
dc.contributor.alternativeName왕희정-
dc.contributor.alternativeName한규훈-
dc.contributor.alternativeName조혜성-
dc.identifier.bibliographicCitationOncotarget, vol. 5, no. 23, pp. 12233-12246-
dc.identifier.doi10.18632/oncotarget.2625-
dc.subject.keywordCatalase-
dc.subject.keywordCysteine-
dc.subject.keywordHBx-
dc.subject.keywordLiver cancer-
dc.subject.keywordROS-
dc.subject.localCatalase-
dc.subject.localcatalase-
dc.subject.localCysteine-
dc.subject.localcysteine-
dc.subject.localHBX-
dc.subject.localHBx-
dc.subject.localLiver cancer-
dc.subject.localliver cancer-
dc.subject.localLiver Cancer-
dc.subject.localReactive oxidative species-
dc.subject.localReactive oxygen species(ROS)-
dc.subject.localReactive oxygen species-
dc.subject.localReactive Oxygen Species (ROS)-
dc.subject.localReactive Oxygen Species-
dc.subject.localROS-
dc.subject.localReactive oxygen species (ROS)-
dc.subject.localreactive oxygen species-
dc.subject.localreactive oxygen species (ROS)-
dc.description.journalClassN-
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