Two new lignans from Saururus chinensis and their DGAT inhibitory activity

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Title
Two new lignans from Saururus chinensis and their DGAT inhibitory activity
Author(s)
N Li; Z D Tuo; S Z Qi; S S Xing; Hyun Sun Lee; J G Chen; L Cui
Bibliographic Citation
Fitoterapia, vol. 101, pp. 46-50
Publication Year
2015
Abstract
Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3 ± 1.5 to 87.5 ± 1.3 μM.
Keyword
DGATLignanSaururaceaeSaururus chinensis
ISSN
0367-326X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.fitote.2014.12.011
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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