Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure

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dc.contributor.authorJ H Kim-
dc.contributor.authorP Gripon-
dc.contributor.authorF Bouezzedine-
dc.contributor.authorM S Jeong-
dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorS E Ryu-
dc.contributor.authorH J Hong-
dc.date.accessioned2017-04-19T10:01:04Z-
dc.date.available2017-04-19T10:01:04Z-
dc.date.issued2015-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/j.febslet.2014.11.046ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12418-
dc.description.abstractTo improve a previously constructed broadly neutralizing hepatitis B virus (HBV)-specific preS1 humanized antibody (HzKR127), we further humanized it through specificity-determining residue (SDR) grafting. Moreover, we improved affinity by mutating two residues in heavy-chain complementarity-determining regions (CDR), on the basis of the crystal structure of the antigen-antibody complex. HzKR127-3.2 exhibited 2.5-fold higher affinity and enhanced virus-neutralizing activity compared to the original KR127 antibody and showed less immunogenic potential than HzKR127. Enhanced virus-neutralizing activity was achieved by the increased association rate, providing insights into engineering potent antibody therapeutics for HBV immunoprophylaxis. HzKR127-3.2 may be a good candidate for HBV immunoprophylaxis.-
dc.publisherWiley-
dc.titleEnhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure-
dc.title.alternativeEnhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number2-
dc.citation.endPage200-
dc.citation.startPage193-
dc.citation.volume589-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.alternativeName김진홍-
dc.contributor.alternativeNameGripon-
dc.contributor.alternativeNameBouezzedine-
dc.contributor.alternativeName정문식-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeName류성언-
dc.contributor.alternativeName홍효정-
dc.identifier.bibliographicCitationFEBS Letters, vol. 589, no. 2, pp. 193-200-
dc.identifier.doi10.1016/j.febslet.2014.11.046-
dc.subject.keywordAffinity maturation-
dc.subject.keywordHepatitis B virus-
dc.subject.keywordHumanized antibody-
dc.subject.keywordpreS1-
dc.subject.keywordSpecificity-determining residue grafting-
dc.subject.keywordVirus neutralization-
dc.subject.localaffinity maturation-
dc.subject.localaffinity Maturation-
dc.subject.localAffinity maturation-
dc.subject.localhepatitis B virus (HBV)-
dc.subject.localHepatitis B Virus-
dc.subject.localHepatitis B virus (HBV)-
dc.subject.localhepatitis B virus-
dc.subject.localhepatitis B Virus (HBV)-
dc.subject.localHepatitis B virus-
dc.subject.localHumanized antibody-
dc.subject.localhumanized antibodies-
dc.subject.localhumanized antibody-
dc.subject.localPreS1-
dc.subject.localpreS1-
dc.subject.localSpecificity-determining residue grafting-
dc.subject.localVirus neutralization-
dc.description.journalClassY-
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Division of Biomedical Research > 1. Journal Articles
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