A pre-structured helix in the intrinsically disordered 4EBP1

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Title
A pre-structured helix in the intrinsically disordered 4EBP1
Author(s)
Do-Hyoung Kim; Chewook Lee; Ye-Jin Cho; Si-Hyung Lee; Eun Ji Cha; Ji Eun Lim; T M Sabo; C Griesinger; D Lee; Kyou Hoon Han
Bibliographic Citation
Molecular Biosystems, vol. 11, no. 2, pp. 366-369
Publication Year
2015
Abstract
The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
ISSN
1742-206X
Publisher
Royal Soc Chemistry
DOI
http://dx.doi.org/10.1039/c4mb00532e
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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