Open Access@KRIBBDivision of Bio Technology InnovationCore Research Facility & Analysis Center1. Journal Articles
A pre-structured helix in the intrinsically disordered 4EBP1
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- Title
- A pre-structured helix in the intrinsically disordered 4EBP1
- Author(s)
- Do-Hyoung Kim; Chewook Lee; Ye-Jin Cho; Si-Hyung Lee; Eun Ji Cha; Ji Eun Lim; T M Sabo; C Griesinger; D Lee; Kyou Hoon Han
- Bibliographic Citation
- Molecular Biosystems, vol. 11, no. 2, pp. 366-369
- Publication Year
- 2015
- Abstract
- The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
- ISSN
- 1742-206X
- Publisher
- Royal Soc Chemistry
- Full Text Link
- http://dx.doi.org/10.1039/c4mb00532e
- Type
- Article
- Appears in Collections:
- Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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