Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/beta-catenin signaling

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dc.contributor.authorYeong Jae Bahn-
dc.contributor.authorKwang-Pyo Lee-
dc.contributor.authorSeung Min Lee-
dc.contributor.authorJeong Yi Choi-
dc.contributor.authorY S Seo-
dc.contributor.authorKi Sun Kwon-
dc.date.accessioned2017-04-19T10:01:33Z-
dc.date.available2017-04-19T10:01:33Z-
dc.date.issued2015-
dc.identifier.issn00222275-
dc.identifier.uri10.1194/jlr.M054056ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12432-
dc.description.abstractNucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the early adipogenic stage of 3T3-L1 preadipocyte differentiation. Knockdown of NRX decreased differentiation of 3T3-L1 cells, whereas overexpression increased differentiation. Adipose tissuespecifi c NRX transgenic mice showed increases in adipocyte size as well as number compared with WT mice. We further confi rmed that the Wingless/int-1 class (Wnt) /β -catenin pathway was also involved in NRX-promoted adipogenesis, consistent with a previous report showing NRX regulation of this pathway. Genes involved in lipid metabolism were downregulated, whereas inflammatory genes, including those encoding macrophage markers, were signifi cantly upregulated, likely contributing to the obesity in Adipo-NRX mice. Our results therefore suggest that NRX acts as a novel proadipogenic factor and controls obesity in vivo. - Bahn, Y. J., K-P. Lee, S-M. Lee, J. Y. Choi, Y-S. Seo, and K-S. Kwon. Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/β -catenin signaling. J. Lipid Res. 2015. 56: 294-303.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleNucleoredoxin promotes adipogenic differentiation through regulation of Wnt/beta-catenin signaling-
dc.title.alternativeNucleoredoxin promotes adipogenic differentiation through regulation of Wnt/beta-catenin signaling-
dc.typeArticle-
dc.citation.titleJournal of Lipid Research-
dc.citation.number2-
dc.citation.endPage303-
dc.citation.startPage294-
dc.citation.volume56-
dc.contributor.affiliatedAuthorKwang-Pyo Lee-
dc.contributor.affiliatedAuthorSeung Min Lee-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.alternativeName반영재-
dc.contributor.alternativeName이광표-
dc.contributor.alternativeName이승민-
dc.contributor.alternativeName최정이-
dc.contributor.alternativeName서연수-
dc.contributor.alternativeName권기선-
dc.identifier.bibliographicCitationJournal of Lipid Research, vol. 56, no. 2, pp. 294-303-
dc.identifier.doi10.1194/jlr.M054056-
dc.subject.keywordAdipogenesis-
dc.subject.keywordInflammation-
dc.subject.keywordObesity-
dc.subject.keywordWingless/int-1 class(wnt) signaling-
dc.subject.localAdipogenesis-
dc.subject.localInflammation-
dc.subject.localObesity-
dc.subject.localWingless/int-1 class(wnt) signaling-
dc.description.journalClassY-
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Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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