Genome-wide copy number variation in a Korean native chicken breed = 한국 토종닭의 전장 유전체 복제수변이(CNV) 발굴

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Title
Genome-wide copy number variation in a Korean native chicken breed = 한국 토종닭의 전장 유전체 복제수변이(CNV) 발굴
Author(s)
E S Cho; Won-Hyong Chung; J W Choi; H J Jang; M N Park; Namshin Kim; T H Kim; K T Lee
Bibliographic Citation
Korean Journal of Poultry Science, vol. 41, no. 4, pp. 305-311
Publication Year
2014
Abstract
Copy number variation (CNV) is a form of structural variation that shows various numbers of copies in segments of the DNA. It has been shown to account for phenotypic variations in human diseases and agricultural production traits. Currently, most of chicken breeds in the poultry industry are based on European-origin breeds that have been mostly provided from several international breeding companies. Therefore, National Institute of Animal Science, RDA has been trying to restore and improve Korean native chicken breeds (12 lines of 5 breeds) for about 20 years. Thanks to the recent advance of sequencing technologies, genome-wide CNV can be accessed in the higher resolution throughout the genome of species of interest. However, there is no systematic study available to dissect the CNV in the native chicken breed in Korea. Here, we report genome-wide copy number variations identified from a genome of Korean native chicken (Line L) by comparing between the chicken reference sequence assembly (Gallus gallus) and a de novo sequencing assembly of the Korean native chicken (Line L). Throughout all twenty eight chicken autosomes, we identified a total of 501 CNVs; defined as gain and loss of duplication and deletion respectively. Furthermore, we performed gene ontology (GO) analysis for the putative CNVs using DAVID, leading to 68 GO terms clustered independently. Of the clustered GO terms, genes related to transcription and gene regulation were mainly detected. This study provides useful genomic resource to investigate potential biological implications of CNVs with traits of interest in the Korean native chicken.
Keyword
copy number variationKorean native chickende novo sequencing
ISSN
1225-6625
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5536/KJPS.2014.41.4.305
Type
Article
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1. Journal Articles > Journal Articles
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