DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Won Park | - |
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Jung Hee Kim | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | J H Kim | - |
dc.contributor.author | Jin Hyub Paik | - |
dc.contributor.author | B Marwoto | - |
dc.contributor.author | R Widjhati | - |
dc.contributor.author | F Juniarti | - |
dc.contributor.author | D Irawan | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.date.accessioned | 2017-04-19T10:01:59Z | - |
dc.date.available | 2017-04-19T10:01:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | 10.3892/ijmm.2015.2107 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12463 | - |
dc.description.abstract | Rhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti-inflammatory properties. In the present study, we screened RA extracts with anti-inflammatory properties. The biological effects of an RA methanol extract (RAME) on inflammation were investigated in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cells. We investigated the effects of RAME on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of RAME, we measured the mRNA and protein expression of pro-inflammatory mediators induced by RAME in the LPS-stimulated RAW264.7 cells by RT-PCR and western blot analysis, respectively. RAME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in the LPS-stimulated RAW264.7 cells. It also suppressed the mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases (MAPKs) with a concomitant decrease in the nuclear translocation of nuclear factor-κB (NF-κB) in the LPS-stimulated RAW264.7 cells. These results indicate that RAME inhibits LPS-induced inflammatory responses. These effects were considered to be strongly associated with the suppression of NF-κB activation. We therefore suggest that RAME may be prove to be an effective therapeutic agent for the treatment of inflammatory diseases. | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Rhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-kB signaling = 로도덴드론의 iNOS와 COX-2 저해효과 | - |
dc.title.alternative | Rhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-kB signaling | - |
dc.type | Article | - |
dc.citation.title | International Journal of Molecular Medicine | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 994 | - |
dc.citation.startPage | 987 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Ji Won Park | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Jung Hee Kim | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.affiliatedAuthor | Jin Hyub Paik | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.alternativeName | 박지원 | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 김정희 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 김재홍 | - |
dc.contributor.alternativeName | 백진협 | - |
dc.contributor.alternativeName | Marwoto | - |
dc.contributor.alternativeName | Widjhati | - |
dc.contributor.alternativeName | Juniarti | - |
dc.contributor.alternativeName | Irawan | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Medicine, vol. 35, no. 4, pp. 987-994 | - |
dc.identifier.doi | 10.3892/ijmm.2015.2107 | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Lipopolysaccharide | - |
dc.subject.keyword | Mitogen-activated protein kinases | - |
dc.subject.keyword | Nuclear factor-κB | - |
dc.subject.keyword | Rhododendron album Blume | - |
dc.subject.local | Inflammation | - |
dc.subject.local | inflammation | - |
dc.subject.local | nflammation | - |
dc.subject.local | Lipopolysaccharide | - |
dc.subject.local | Lipopolysaccharide (LPS) | - |
dc.subject.local | Lipopolysaccharides | - |
dc.subject.local | lipopolysaccharide | - |
dc.subject.local | lipopolysaccharide (LPS) | - |
dc.subject.local | mitogen activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinases | - |
dc.subject.local | Mitogen activated protein kinase | - |
dc.subject.local | Mitogen-acti-vated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase (MAPK) | - |
dc.subject.local | Mitogen-activated protein kinases | - |
dc.subject.local | Mitogen-activated protein kinases (MAPKs) | - |
dc.subject.local | Mitogen-activated protein (MAP) kinase | - |
dc.subject.local | Mitogenactivated protein kinase | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Rhododendron album Blume | - |
dc.description.journalClass | Y | - |
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