Rhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-kB signaling = 로도덴드론의 iNOS와 COX-2 저해효과

Cited 19 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJi Won Park-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorJ H Kim-
dc.contributor.authorJin Hyub Paik-
dc.contributor.authorB Marwoto-
dc.contributor.authorR Widjhati-
dc.contributor.authorF Juniarti-
dc.contributor.authorD Irawan-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2017-04-19T10:01:59Z-
dc.date.available2017-04-19T10:01:59Z-
dc.date.issued2015-
dc.identifier.issn1107-3756-
dc.identifier.uri10.3892/ijmm.2015.2107ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12463-
dc.description.abstractRhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti-inflammatory properties. In the present study, we screened RA extracts with anti-inflammatory properties. The biological effects of an RA methanol extract (RAME) on inflammation were investigated in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cells. We investigated the effects of RAME on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of RAME, we measured the mRNA and protein expression of pro-inflammatory mediators induced by RAME in the LPS-stimulated RAW264.7 cells by RT-PCR and western blot analysis, respectively. RAME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in the LPS-stimulated RAW264.7 cells. It also suppressed the mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases (MAPKs) with a concomitant decrease in the nuclear translocation of nuclear factor-κB (NF-κB) in the LPS-stimulated RAW264.7 cells. These results indicate that RAME inhibits LPS-induced inflammatory responses. These effects were considered to be strongly associated with the suppression of NF-κB activation. We therefore suggest that RAME may be prove to be an effective therapeutic agent for the treatment of inflammatory diseases.-
dc.publisherSpandidos Publ Ltd-
dc.titleRhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-kB signaling = 로도덴드론의 iNOS와 COX-2 저해효과-
dc.title.alternativeRhododendron album Blume inhibits iNOS and COX-2 expression in LPS-stimulated RAW264.7 cells through the downregulation of NF-kB signaling-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Medicine-
dc.citation.number4-
dc.citation.endPage994-
dc.citation.startPage987-
dc.citation.volume35-
dc.contributor.affiliatedAuthorJi Won Park-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorJin Hyub Paik-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName박지원-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName김재홍-
dc.contributor.alternativeName백진협-
dc.contributor.alternativeNameMarwoto-
dc.contributor.alternativeNameWidjhati-
dc.contributor.alternativeNameJuniarti-
dc.contributor.alternativeNameIrawan-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationInternational Journal of Molecular Medicine, vol. 35, no. 4, pp. 987-994-
dc.identifier.doi10.3892/ijmm.2015.2107-
dc.subject.keywordInflammation-
dc.subject.keywordLipopolysaccharide-
dc.subject.keywordMitogen-activated protein kinases-
dc.subject.keywordNuclear factor-κB-
dc.subject.keywordRhododendron album Blume-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.subject.locallipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharide-
dc.subject.locallipopolysaccharide-
dc.subject.localLipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharides-
dc.subject.localmitogen-activated protein kinase-
dc.subject.localMitogen activated protein kinase-
dc.subject.localMitogen-activated protein (MAP) kinase-
dc.subject.localmitogen-activated protein kinases-
dc.subject.localMitogen-activated protein kinase (MAPK)-
dc.subject.localMitogen-activated protein kinase-
dc.subject.localMitogenactivated protein kinase-
dc.subject.localmitogen activated protein kinase-
dc.subject.localMitogen-activated protein kinases (MAPKs)-
dc.subject.localMitogen-acti-vated protein kinase-
dc.subject.localMitogen-activated protein kinases-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localRhododendron album Blume-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.