NgR1 expressed in P19 embryonal carcinoma cells differentiated by retinoic acid can activate STAT3

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dc.contributor.authorS I Lee-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorJ Y Baek-
dc.contributor.authorY J Jeong-
dc.contributor.authorJin Ah Kim-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorS H Park-
dc.contributor.authorS K Kim-
dc.contributor.authorS K Park-
dc.date.accessioned2017-04-19T10:02:04Z-
dc.date.available2017-04-19T10:02:04Z-
dc.date.issued2015-
dc.identifier.issn12264512-
dc.identifier.uri10.4196/kjpp.2015.19.2.105ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12479-
dc.description.abstractNgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells using all trans-retinoic acid and the presence and/or function of cellular molecules, such as NgR1, NMDA receptors and STAT3, were examined. Neuronally differentiated P19 cells expressed the mRNA and protein of NgR1, which could stimulate the phosphorylation of STAT3 when activated by Nogo-P4 peptide, an active segment of Nogo-66. During the whole period of differentiation, mRNAs of all of the NMDA receptor subtypes tested (NR1, NR2A-2D) were consistently expressed, which meant that neuronally differentiated P19 cells maintained some characteristics of neurons, especially central nervous system neurons. Our results suggests that neuronally differentiated P19 cells expressing NgR1 may be an efficient and convenient in vitro model for studying the molecular mechanism of cellular events that involve NgR1 and its binding partners, and for screening compounds that activate or inhibit NgR1.-
dc.publisherSouth Korea-
dc.titleNgR1 expressed in P19 embryonal carcinoma cells differentiated by retinoic acid can activate STAT3-
dc.title.alternativeNgR1 expressed in P19 embryonal carcinoma cells differentiated by retinoic acid can activate STAT3-
dc.typeArticle-
dc.citation.titleKorean Journal of Physiology & Pharmacology-
dc.citation.number2-
dc.citation.endPage109-
dc.citation.startPage105-
dc.citation.volume19-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName이수인-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName백지영-
dc.contributor.alternativeName정연지-
dc.contributor.alternativeName김진아-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName박선홍-
dc.contributor.alternativeName김상겸-
dc.contributor.alternativeName박성규-
dc.identifier.bibliographicCitationKorean Journal of Physiology & Pharmacology, vol. 19, no. 2, pp. 105-109-
dc.identifier.doi10.4196/kjpp.2015.19.2.105-
dc.subject.keywordNeuronal differentiation-
dc.subject.keywordNMDA receptor-
dc.subject.keywordNogo receptor-
dc.subject.keywordP19 cell-
dc.subject.keywordSTAT3-
dc.subject.localNeuronal differentiation-
dc.subject.localNMDA receptor-
dc.subject.localNogo receptor-
dc.subject.localP19 cell-
dc.subject.localSTAT3-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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