Genome-wide identification and classification of microRNAs derived from repetitive elements

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Title
Genome-wide identification and classification of microRNAs derived from repetitive elements
Author(s)
J A Gim; H S Ha; K Ahn; Dae Soo Kim; H S Kim
Bibliographic Citation
Genomics & Informatics, vol. 12, no. 4, pp. 261-267
Publication Year
2014
Abstract
MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.
Keyword
interspersed repetitive sequencesmicroRNAnovel miRNAspalindromic structure
ISSN
I000-0158
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5808/GI.2014.12.4.261
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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