Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody

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dc.contributor.authorByngtae Hwang-
dc.contributor.authorSang Hyun Lee-
dc.contributor.authorJang Seong Kim-
dc.contributor.authorji Hyun Moon-
dc.contributor.authorI C Jeung-
dc.contributor.authorNa Geum Lee-
dc.contributor.authorJongjin Park-
dc.contributor.authorH J Hong-
dc.contributor.authorYoung Lai Cho-
dc.contributor.authorHaiyoung Jung-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorSeon-Jin Lee-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorWon Kon Kim-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorS J Chung-
dc.contributor.authorY G Kwon-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorSang Jick Kim-
dc.contributor.authorJeong Ki Min-
dc.date.accessioned2017-04-19T10:02:23Z-
dc.date.available2017-04-19T10:02:23Z-
dc.date.issued2015-
dc.identifier.issn0142-9612-
dc.identifier.uri10.1016/j.biomaterials.2015.01.062ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12501-
dc.description.abstractAngiopoietin-1 (Ang1) and its endothelium-specific receptor, tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2), play critical roles in vascular development. Although the Ang1/Tie2 system has been considered a promising target for therapeutic neovascularization, several imitations of large-scale production have hampered the development of recombinant Ang1 for therapeutics. In this study, we produced a fully human agonistic antibody against Tie2, designated 1-4h, and tested the applicability of 1-4h as an alternative to native Ang1 in therapeutic angiogenesis. 1-4h significantly enhanced the phosphorylation of Tie2 in a dose- and time-dependent manner in human Tie2-expressing HEK293 cells and human umbilical vein endothelial cells. Moreover, 1-4h induced the activation of Tie2-mediated intracellular signaling such as AKT, eNOS, MAPK, and Focal Adhesion Kinase p125FAK. In addition, 1-4h increased the chemotactic motility and capillary-like tube formation of endothelial cells invitro and enhanced the survival of serum-deprived endothelial cells. Taken together, our data clearly suggest that a human Tie2 agonistic antibody is a potentially useful therapeutic approach for the treatment of several ischemic diseases including delayed-wound healing and ischemic heart and limb diseases.-
dc.publisherElsevier-
dc.titleStimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody-
dc.title.alternativeStimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody-
dc.typeArticle-
dc.citation.titleBiomaterials-
dc.citation.number0-
dc.citation.endPage128-
dc.citation.startPage119-
dc.citation.volume51-
dc.contributor.affiliatedAuthorByngtae Hwang-
dc.contributor.affiliatedAuthorSang Hyun Lee-
dc.contributor.affiliatedAuthorJang Seong Kim-
dc.contributor.affiliatedAuthorji Hyun Moon-
dc.contributor.affiliatedAuthorNa Geum Lee-
dc.contributor.affiliatedAuthorJongjin Park-
dc.contributor.affiliatedAuthorYoung Lai Cho-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorSeon-Jin Lee-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.affiliatedAuthorSang Jick Kim-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.alternativeName황병태-
dc.contributor.alternativeName이상현-
dc.contributor.alternativeName김장성-
dc.contributor.alternativeName문지현-
dc.contributor.alternativeName정인철-
dc.contributor.alternativeName이나금-
dc.contributor.alternativeName박종진-
dc.contributor.alternativeName홍효정-
dc.contributor.alternativeName조영래-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName이선진-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName권영근-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName김상직-
dc.contributor.alternativeName민정기-
dc.identifier.bibliographicCitationBiomaterials, vol. 51, pp. 119-128-
dc.identifier.doi10.1016/j.biomaterials.2015.01.062-
dc.subject.keywordAgonistic antibody-
dc.subject.keywordAngiogenesis-
dc.subject.keywordAngiopoietin-1-
dc.subject.keywordTie2 receptor-
dc.subject.localAgonistic antibody-
dc.subject.localAngiogenesis-
dc.subject.localangiogenesis-
dc.subject.localAngiopoietin-1-
dc.subject.localTie2 receptor-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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