Defense strategies for removing a highly toxic intermediate of glycerol reductive metabolism in Klebsiella pneumoniae = Klebsiella pneumoniae 글리세롤 환원대사에서 독성중간물질의 제거를 위한 방어 기작

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Title
Defense strategies for removing a highly toxic intermediate of glycerol reductive metabolism in Klebsiella pneumoniae = Klebsiella pneumoniae 글리세롤 환원대사에서 독성중간물질의 제거를 위한 방어 기작
Author(s)
Jeong-Woo Seo; L H Luo; Baek Rock OhSun-Yeon Heo; Won-Kyung Hong; Ji Young KangChul Ho Kim
Bibliographic Citation
Current Topics in Biotechnology, vol. 8, pp. 35-38
Publication Year
2015
Abstract
Klebsiella pneumoniae is known to have evolved two mechanisms for preventing accumulation of the highly toxic intermediate 3-hydroxypropionaldehyde during reductive glycerol metabolism in which the toxic intermediate is converted to 3-hydroxypropionic acid (3-HP). One metabolic pathway, which involves a propanediol-utilization protein (PduP), is important under late-stage growth conditions at which concentrations of 1,3-propanediol are high. The other is a non-specific mechanism that removes intracellur toxic aldehyde molecules by reactions catalyzed by various aldehyde dehydrogenases. These microbial metabolic pathways could find application in industry for the synthesis of 3-HP, which is a useful platform chemical.
Keyword
3-hydroxypropionic acid3-hydroxypropion aldehydeproanediol-utilization protein
ISSN
0972-821X
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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