Phytoecdysones from the roots of Achyranthes japonica Nakai and their anti-atopy activity = 우슬의 뿌리로부터 Phytoecdysones의 분리와 항 아토피 효과

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Title
Phytoecdysones from the roots of Achyranthes japonica Nakai and their anti-atopy activity = 우슬의 뿌리로부터 Phytoecdysones의 분리와 항 아토피 효과
Author(s)
Ki Ohk Kim; C S Ku; M J Kim; Yhun Jung Park; Hyung Won Ryu; Hyuk-Hwan Song; Jung Hee KimSei-Ryang Oh
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 58, no. 1, pp. 13-19
Publication Year
2015
Abstract
The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling. Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-inokosterone (2), and 25R-inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80?95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.
Keyword
Achyranthis radixAnti-atopyPhytoecdysones
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2015.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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