Cosmetic activities of nyasol from the rhizomes of Anemarrhena asphodeloide = 지모의 뿌리줄기로부터 분리된 nyasol의 미용효과

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Title
Cosmetic activities of nyasol from the rhizomes of Anemarrhena asphodeloide = 지모의 뿌리줄기로부터 분리된 nyasol의 미용효과
Author(s)
Yhun Jung Park; C S Ku; M J Kim; M K Lee; Ki Ohk Kim; Hyung Won Ryu; Hyuk-Hwan Song; Doo-Young KimSei-Ryang Oh
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 58, no. 1, pp. 31-38
Publication Year
2015
Abstract
The rhizomes of Anemarrhena asphodeloide was extracted with 100% ethanol and concentrated subfractions were separated with medium pressure liquid chromatography-based activity profiling. One compound was isolated from the subfraction 10 through the repeated preparative high performance liquid chromatography (prep-HPLC). According to physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compound was determined as nyasol (1). Nyasol was exhibited potent inhibitory activity for NO (IC50: 12.5 μg/mL), tyrosinase (IC50: 12.5 μg/mL), melanin contents (IC50: 12.5 μg/mL), thymus and activation-regulated chemokine (TARC) production (IC50: 6.25 μg/mL). As a result, nyasol has an excellent inflammation-dependent anti-whitening and TARC production activity. It could be used to a large range of functional cosmetics.
Keyword
Anemarrhena asphodeloideAnti-atopyAnti-whiteningNitric oxideNyaso
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2015.007
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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