Effects of palm and sunflower oils on serum cholesterol and fatty liver in rats

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dc.contributor.authorR E Go-
dc.contributor.authorK A Hwang-
dc.contributor.authorY S Kim-
dc.contributor.authorS H Kim-
dc.contributor.authorKi Hoan Nam-
dc.contributor.authorK C Choi-
dc.date.accessioned2017-04-19T10:02:33Z-
dc.date.available2017-04-19T10:02:33Z-
dc.date.issued2015-
dc.identifier.issn1096-620X-
dc.identifier.uri10.1089/jmf.2014.3163ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12516-
dc.description.abstractPalm oil is a common cooking ingredient used in the commercial food industry as the second largest consumed vegetable oil in the world. Because of its lower cost and highly saturated nature, it usually maintains a solid form at room temperature and is used as a cheap substitute for butter. However, there has been a growing health concern about palm oil because of the link between dietary fats and coronary heart disease. Palm oil contains 49% saturated fat, a relatively high concentration compared with other vegetable oils. Consequently, high intakes of saturated fat from palm oil induce a larger increase in plasma concentrations of total cholesterol and low-density lipoproteins. In the present study, we examined the hyperlipidemia of palm oil and the risk of cardiovascular disease (CVD) using a rat model in comparison with sunflower oil with a relatively low level of saturated fat. On in vivo examination using Sprague-Dawley (SD) rats for 22 days, there were no significant differences in serum lipid levels, suggesting that palm oil may not cause hyperlipidemia and elevate CVD risk. However, liver samples obtained from SD rats fed with palm oil showed a lot of large lipid inclusions stained with the Oil Red O working solution, but not much lipid accumulation was observed in rats treated with sunflower oil. In addition, lipid accumulation in the mixed oil group fed the combination of palm and sunflower (1:1) oil was shown to be at an intermediary level between the palm oil group and sunflower oil group. Taken together, these results indicate that palm oil, a highly saturated form of vegetable oil, may induce dysfunction of the liver lipid metabolism before affecting serum lipid levels. On the other hand, sunflower oil, a highly unsaturated vegetable oil, was shown to be well metabolized in liver. ⓒ Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2015.-
dc.publisherMary Ann Liebert, Inc-
dc.titleEffects of palm and sunflower oils on serum cholesterol and fatty liver in rats-
dc.title.alternativeEffects of palm and sunflower oils on serum cholesterol and fatty liver in rats-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number3-
dc.citation.endPage369-
dc.citation.startPage363-
dc.citation.volume18-
dc.contributor.affiliatedAuthorKi Hoan Nam-
dc.contributor.alternativeName고예은-
dc.contributor.alternativeName황경아-
dc.contributor.alternativeName김예슬-
dc.contributor.alternativeName김승희-
dc.contributor.alternativeName남기환-
dc.contributor.alternativeName최경철-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 18, no. 3, pp. 363-369-
dc.identifier.doi10.1089/jmf.2014.3163-
dc.subject.keywordcholesterol-
dc.subject.keywordfatty liver-
dc.subject.keywordpalm oil-
dc.subject.keywordsunflower oil-
dc.subject.keywordtriglyceride-
dc.subject.localcholesterol-
dc.subject.localCholesterol-
dc.subject.localFatty liver-
dc.subject.localfatty liver-
dc.subject.localpalm oil-
dc.subject.localsunflower oil-
dc.subject.localtriglyceride-
dc.subject.localTriglycerides-
dc.subject.localTriglyceride-
dc.subject.localtriglyceride (TG)-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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