Anti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury = 카나리움 추출물의 항염효과

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dc.contributor.authorJu Mi Hong-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorChan Mi Jeon-
dc.contributor.authorNa Rae Shin-
dc.contributor.authorJoongku Lee-
dc.contributor.authorSang-Hong Park-
dc.contributor.authorT Bach-
dc.contributor.authorD V Hai-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorS B Han-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2017-04-19T10:02:38Z-
dc.date.available2017-04-19T10:02:38Z-
dc.date.issued2015-
dc.identifier.issn1107-3756-
dc.identifier.uri10.3892/ijmm.2015.2117ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12523-
dc.description.abstractCanarium lyi C.D. Dai & Yakovlev (CL) is a member of the Anacardiaceae family. To the best of our knowledge, no studies on its anti-inflammatory effects have yet been reported. In the present study, we investigated the protective effects of CL on inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and LPS-induced acute lung injury (ALI) mice. CL attenuated the production of LPS-stimulated inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and interleukin-6 (IL-6). Furthermore, CL suppressed phosphorylation of the inhibitor κB-α (IκB-α), p38, c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK), as well as the translocation of the nuclear factor-κB (NF-κB) p65 subunit into the nucleus. For the in vivo efficacy, the effect of CL on a mouse model of LPS-induced acute lung injury was assessed. CL treatment of the mice significantly inhibited the inflammatory cell recruitment and pro-inflammatory cytokine production in bronchoalveolar lavage fluids (BALF). CL-treated mice also showed a marked inhibition of cyclooxygenase-2 (COX-2) and phosphorylation of IκB and p65. In addition, CL attenuated lung histopathological changes in LPS-induced ALI mice. In conclusion, our results suggest that CL is a potential therapeutic candidate for the treatment of inflammatory diseases, including pneumonia.-
dc.publisherSpandidos Publ Ltd-
dc.titleAnti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury = 카나리움 추출물의 항염효과-
dc.title.alternativeAnti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Medicine-
dc.citation.number0-
dc.citation.endPage1410-
dc.citation.startPage1403-
dc.citation.volume35-
dc.contributor.affiliatedAuthorJu Mi Hong-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.affiliatedAuthorChan Mi Jeon-
dc.contributor.affiliatedAuthorNa Rae Shin-
dc.contributor.affiliatedAuthorJoongku Lee-
dc.contributor.affiliatedAuthorSang-Hong Park-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName홍주미-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName전찬미-
dc.contributor.alternativeName신나래-
dc.contributor.alternativeName이중구-
dc.contributor.alternativeName박상홍-
dc.contributor.alternativeNameBach-
dc.contributor.alternativeNameHai-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationInternational Journal of Molecular Medicine, vol. 35, pp. 1403-1410-
dc.identifier.doi10.3892/ijmm.2015.2117-
dc.subject.keywordAcute lung injury-
dc.subject.keywordCanarium lyi C.D. Dai & Yakovlev-
dc.subject.keywordInflammation-
dc.subject.keywordLipopolysaccharide-
dc.subject.localAcute lung injury-
dc.subject.localacute lung injury-
dc.subject.localAcute Lung Injury-
dc.subject.localacute lung injury (ALI)-
dc.subject.localCanarium lyi C.D. Dai & Yakovlev-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.subject.locallipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharide-
dc.subject.locallipopolysaccharide-
dc.subject.localLipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharides-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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