DC Field | Value | Language |
---|---|---|
dc.contributor.author | M L Cohen | - |
dc.contributor.author | Sunhong Kim | - |
dc.contributor.author | K Morita | - |
dc.contributor.author | Seong Heon Kim | - |
dc.contributor.author | M Han | - |
dc.date.accessioned | 2017-04-19T10:02:45Z | - |
dc.date.available | 2017-04-19T10:02:45Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.uri | 10.1371/journal.pgen.1005099 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12526 | - |
dc.description.abstract | Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progression. Key genes in this regulatory network are phylogenetically conserved and include the post-transcriptional microRNA repressor LIN-28; the nuclear hormone receptor DAF-12; and the microRNAs LIN-4, LET-7, and the three LET-7 family miRNAs (miR-48, miR-84, and miR-241). DAF-12 is known to regulate transcription of miR-48, miR-84 and miR-241, but its contribution is insufficient to account for all of the transcriptional regulation implied by the mutant phenotypes. In this work, the GATA-family transcription factor ELT-1 is identified from a genetic enhancer screen as a regulator of developmental timing in parallel to DAF-12, and is shown to do so by promoting the expression of the LET-7, miR-48, miR-84, and miR-241 microRNAs. The role of ELT-1 in developmental timing is shown to be separate from its role in cell-fate maintenance during post-embryonic development. In addition, analysis of Chromatin Immnoprecipitation (ChIP) data from the modENCODE project and this work suggest that the contribution of ELT-1 to the control of let-7 family microRNA expression is likely through direct transcription regulation. | - |
dc.publisher | Public Library of Science | - |
dc.title | The GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs | - |
dc.title.alternative | The GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs | - |
dc.type | Article | - |
dc.citation.title | PLoS Genetics | - |
dc.citation.number | 3 | - |
dc.citation.endPage | e1005099 | - |
dc.citation.startPage | e1005099 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Sunhong Kim | - |
dc.contributor.affiliatedAuthor | Seong Heon Kim | - |
dc.contributor.alternativeName | Cohen | - |
dc.contributor.alternativeName | 김선홍 | - |
dc.contributor.alternativeName | Morita | - |
dc.contributor.alternativeName | 김성헌 | - |
dc.contributor.alternativeName | 한민 | - |
dc.identifier.bibliographicCitation | PLoS Genetics, vol. 11, no. 3, pp. e1005099-e1005099 | - |
dc.identifier.doi | 10.1371/journal.pgen.1005099 | - |
dc.description.journalClass | Y | - |
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