The GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs

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dc.contributor.authorM L Cohen-
dc.contributor.authorSunhong Kim-
dc.contributor.authorK Morita-
dc.contributor.authorSeong Heon Kim-
dc.contributor.authorM Han-
dc.date.accessioned2017-04-19T10:02:45Z-
dc.date.available2017-04-19T10:02:45Z-
dc.date.issued2015-
dc.identifier.issn1553-7390-
dc.identifier.uri10.1371/journal.pgen.1005099ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12526-
dc.description.abstractPostembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progression. Key genes in this regulatory network are phylogenetically conserved and include the post-transcriptional microRNA repressor LIN-28; the nuclear hormone receptor DAF-12; and the microRNAs LIN-4, LET-7, and the three LET-7 family miRNAs (miR-48, miR-84, and miR-241). DAF-12 is known to regulate transcription of miR-48, miR-84 and miR-241, but its contribution is insufficient to account for all of the transcriptional regulation implied by the mutant phenotypes. In this work, the GATA-family transcription factor ELT-1 is identified from a genetic enhancer screen as a regulator of developmental timing in parallel to DAF-12, and is shown to do so by promoting the expression of the LET-7, miR-48, miR-84, and miR-241 microRNAs. The role of ELT-1 in developmental timing is shown to be separate from its role in cell-fate maintenance during post-embryonic development. In addition, analysis of Chromatin Immnoprecipitation (ChIP) data from the modENCODE project and this work suggest that the contribution of ELT-1 to the control of let-7 family microRNA expression is likely through direct transcription regulation.-
dc.publisherPublic Library of Science-
dc.titleThe GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs-
dc.title.alternativeThe GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs-
dc.typeArticle-
dc.citation.titlePLoS Genetics-
dc.citation.number3-
dc.citation.endPagee1005099-
dc.citation.startPagee1005099-
dc.citation.volume11-
dc.contributor.affiliatedAuthorSunhong Kim-
dc.contributor.affiliatedAuthorSeong Heon Kim-
dc.contributor.alternativeNameCohen-
dc.contributor.alternativeName김선홍-
dc.contributor.alternativeNameMorita-
dc.contributor.alternativeName김성헌-
dc.contributor.alternativeName한민-
dc.identifier.bibliographicCitationPLoS Genetics, vol. 11, no. 3, pp. e1005099-e1005099-
dc.identifier.doi10.1371/journal.pgen.1005099-
dc.description.journalClassY-
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