Functional restoration of exhausted CD4+ and CD8+ T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa

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dc.contributor.authorE Uyangaa-
dc.contributor.authorJ Y Choi-
dc.contributor.authorA M Patil-
dc.contributor.authorJ H Kim-
dc.contributor.authorS B Kim-
dc.contributor.authorK Kim-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorS K Eo-
dc.date.accessioned2017-04-19T10:02:48Z-
dc.date.available2017-04-19T10:02:48Z-
dc.date.issued2015-
dc.identifier.issn0147-9571-
dc.identifier.uri10.1016/j.cimid.2015.02.001ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12535-
dc.description.abstractT-cell exhaustion has become an important issue in chronic infection because exhausted antigen-specific T cells show impaired abilities to eradicate persistently infected pathogens and produce effector cytokines, such as IFN-γ and TNF-α. Thus, strategies to either restore endogenous exhausted T cell responses or provide functional T cells are needed for therapeutics of chronic infection. Despite promising developments using antibodies and cell immunotherapy, there have been no reported attempts to restore exhausted T cells using treatment with materials derived from natural resources. Here, using a mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV), we found that vinegar-processed flowers (flos) of Daphne genkwa (vp-genkwa), which was composed mainly of four index components, restored exhausted CD4+ and CD8+ T cells significantly, as corroborated by evidence that vp-genkwa treatment enhanced functional LCMV-specific CD4+ and CD8+ T cells, both quantitatively and qualitatively. Furthermore, pretreatment with vp-genkwa prevented the generation of exhausted LCMV-specific CD8+ T cells. Such restorations of exhausted LCMV-specific CD4+ and CD8+ T cells by vp-genkwa were closely associated with reduced viral burden in sera and tissues. More interestingly, vp-genkwa treatment induced down-regulation of negative molecules, such as PD-1 and Tim-3, in exhausted CD4+ and CD8+ T cells with more apparent down-regulation of Tim-3, suggesting that Tim-3 molecule may be a major target in restoring exhausted T cell responses. Collectively, these results provide valuable new insights into the use of vp-genkwa to develop a therapeutic strategy for chronic human diseases, such as hepatitis B and C virus, human immunodeficiency virus, and cancers.-
dc.publisherElsevier-
dc.titleFunctional restoration of exhausted CD4+ and CD8+ T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa-
dc.title.alternativeFunctional restoration of exhausted CD4+ and CD8+ T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa-
dc.typeArticle-
dc.citation.titleComparative Immunology Microbiology and Infectious Diseases-
dc.citation.number0-
dc.citation.endPage37-
dc.citation.startPage25-
dc.citation.volume39-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.alternativeNameUyangaa-
dc.contributor.alternativeName최진영-
dc.contributor.alternativeNamePatil-
dc.contributor.alternativeName김진형-
dc.contributor.alternativeName김성범-
dc.contributor.alternativeName김관회-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName어성국-
dc.identifier.bibliographicCitationComparative Immunology Microbiology and Infectious Diseases, vol. 39, pp. 25-37-
dc.identifier.doi10.1016/j.cimid.2015.02.001-
dc.subject.keywordChronic viral infection-
dc.subject.keywordDaphne genkwa-
dc.subject.keywordExhausted T cells-
dc.subject.keywordTim-3 molecule-
dc.subject.keywordVinegar-processed flos-
dc.subject.localChronic viral infection-
dc.subject.localDaphne genkwa-
dc.subject.localExhausted T cells-
dc.subject.localTim-3 molecule-
dc.subject.localVinegar-processed flos-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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