Curcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress

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dc.contributor.authorK M Seong-
dc.contributor.authorM Yu-
dc.contributor.authorKyu-Sun Lee-
dc.contributor.authorS Park-
dc.contributor.authorY W Jin-
dc.contributor.authorK J Min-
dc.date.accessioned2017-04-19T10:02:53Z-
dc.date.available2017-04-19T10:02:53Z-
dc.date.issued2015-
dc.identifier.issn2314-6133-
dc.identifier.uri10.1155/2015/425380ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12542-
dc.description.abstractCurcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 M) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.-
dc.publisherHindawi Ltd-
dc.titleCurcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress-
dc.title.alternativeCurcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress-
dc.typeArticle-
dc.citation.titleBiomed Research International-
dc.citation.number0-
dc.citation.endPage425380-
dc.citation.startPage425380-
dc.citation.volume2015-
dc.contributor.affiliatedAuthorKyu-Sun Lee-
dc.contributor.alternativeName성기문-
dc.contributor.alternativeName유미라-
dc.contributor.alternativeName이규선-
dc.contributor.alternativeName박선후-
dc.contributor.alternativeName진영우-
dc.contributor.alternativeName민경진-
dc.identifier.bibliographicCitationBiomed Research International, vol. 2015, pp. 425380-425380-
dc.identifier.doi10.1155/2015/425380-
dc.description.journalClassY-
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