Structure and apoptotic function of p73

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Title
Structure and apoptotic function of p73
Author(s)
Mi Kyung Yoon; Ji Hyang Ha; Min Sung Lee; Seung-Wook Chi
Bibliographic Citation
BMB Reports, vol. 48, no. 2, pp. 81-90
Publication Year
2015
Abstract
p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.
Keyword
ApoptosisCancer therapyp53 protein familyp73Structure
ISSN
1225-8687
Publisher
South Korea
DOI
http://dx.doi.org/10.5483/BMBRep.2015.48.2.255
Type
Article
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
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