HExDB : a database for epigenetic changes occurring after horse exercise

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Title
HExDB : a database for epigenetic changes occurring after horse exercise
Author(s)
J A Gim; S Lee; Dae Soo Kim; K S Jeong; C P Hong; J H Bae; J W Moon; Y S Choi; B W Cho; H G Cho; J Bhak; H S Kim
Bibliographic Citation
Genes & Genomics, vol. 37, no. 3, pp. 287-294
Publication Year
2015
Abstract
DNA methylation is an essential biochemical modification that regulates gene expression. Exercise induces changes in gene expression that adapt as metabolic changes in the blood. We provide a database for the epigenetic changes after horse exercise (http://www.primate.or.kr/hexdb). Horse Exercise Epigenetic Database (HExDB) explicates the change in genome-wide DNA methylation patterns after exercise. Exercise changes the genome-wide epigenetic patterns, and understanding the regions that change is important for confirming exercise physiological mechanisms. For this purpose, our database provides information on differentially methylated regions after exercise that pass a set threshold. A total of 784 genes based on NCBI RefSeq were identified as differentially methylated in equines after exercise. Our database provides clues for the study of exercise-related epigenetic pathways in the thoroughbred horse.
Keyword
Differentially methylated regionExerciseMeDIP-SeqThoroughbred horseTransposable element
ISSN
1976-9571
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s13258-014-0251-4
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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