Gene expression defines natural changes in mammalian lifespan

Cited 89 time in scopus
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Title
Gene expression defines natural changes in mammalian lifespan
Author(s)
A A Fushan; A A Turanov; S G Lee; E B Kim; A V Lobanov; S H Yim; R Buffenstein; Sang-Rae Lee; Kyu Tae Chang; H Rhee; J S Kim; K S Yang; V N Gladyshev
Bibliographic Citation
Aging Cell, vol. 14, no. 3, pp. 352-365
Publication Year
2015
Abstract
Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life-history traits, and identified the processes and pathways involved. These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.
Keyword
AgingGene expressionLife-history traitsLifespanMammals
ISSN
1474-9718
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/acel.12283
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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