A lactate-induced response to hypoxia = 젖산 매개 저산소 반응

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dc.contributor.authorDong Chul Lee-
dc.contributor.authorHyun Ahm Sohn-
dc.contributor.authorZ Y Park-
dc.contributor.authorSangho Oh-
dc.contributor.authorY K Kang-
dc.contributor.authorK M Lee-
dc.contributor.authorMin Ho Kang-
dc.contributor.authorYe Jin Jang-
dc.contributor.authorSuk Jin Yang-
dc.contributor.authorYoung Ki Hong-
dc.contributor.authorHanmi Noh-
dc.contributor.authorJung Ae Kim-
dc.contributor.authorDong Joon Kim-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorDong Min Kim-
dc.contributor.authorSang Jeon Chung-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorKyung Chan Park-
dc.contributor.authorYoung Il Yeom-
dc.date.accessioned2017-04-19T10:03:26Z-
dc.date.available2017-04-19T10:03:26Z-
dc.date.issued2015-
dc.identifier.issn00928674-
dc.identifier.uri10.1016/j.cell.2015.03.011ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12576-
dc.description.abstractOrganisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia. The stabilized NDRG3 protein binds c-Raf to mediate hypoxia-induced activation of Raf-ERK pathway, promoting angiogenesis and cell growth. Inhibiting cellular lactate production abolishes the NDRG3-mediated hypoxia responses. Our study, therefore, elucidates the molecular basis for lactate-induced hypoxia signaling, which can be exploited for the development of therapies targeting hypoxia-induced diseases. Lactate, a common product of anaerobic metabolism, can promote a hypoxic response independent of HIF. It does so by binding as stabilizing the NDRG3 protein that, in turn, triggers signals for cell growth and angiogenesis.-
dc.publisherElsevier-Cell Press-
dc.titleA lactate-induced response to hypoxia = 젖산 매개 저산소 반응-
dc.title.alternativeA lactate-induced response to hypoxia-
dc.typeArticle-
dc.citation.titleCell-
dc.citation.number3-
dc.citation.endPage609-
dc.citation.startPage595-
dc.citation.volume161-
dc.contributor.affiliatedAuthorDong Chul Lee-
dc.contributor.affiliatedAuthorMin Ho Kang-
dc.contributor.affiliatedAuthorJung Ae Kim-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorKyung Chan Park-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName이동철-
dc.contributor.alternativeName손현암-
dc.contributor.alternativeName박지용-
dc.contributor.alternativeName오상호-
dc.contributor.alternativeName강윤경-
dc.contributor.alternativeName이경민-
dc.contributor.alternativeName강민호-
dc.contributor.alternativeName장예진-
dc.contributor.alternativeName양석진-
dc.contributor.alternativeName홍영기-
dc.contributor.alternativeName노한미-
dc.contributor.alternativeName김정애-
dc.contributor.alternativeName김동준-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName김동민-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName박경찬-
dc.contributor.alternativeName염영일-
dc.identifier.bibliographicCitationCell, vol. 161, no. 3, pp. 595-609-
dc.identifier.doi10.1016/j.cell.2015.03.011-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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