The anoctamin family channel subdued mediates thermal nociception in Drosophila

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The anoctamin family channel subdued mediates thermal nociception in Drosophila
W Jang; Ji Young Kim; S Cui; J Jo; B C Lee; Y Lee; Ki Sun Kwon; C S Park; C Kim
Bibliographic Citation
Journal of Biological Chemistry, vol. 290, no. 4, pp. 2521-2528
Publication Year
Calcium-permeable and thermosensitive transient receptor potential (TRP) channels mediate the nociceptive transduction of noxious temperature in Drosophila nociceptors. However, the underlying molecular mechanisms are not completely understood. Here we find that Subdued, a calcium-activated chloride channel of the Drosophila anoctamin family, functions in conjunction with the thermo-TRPs in thermal nociception. Genetic analysis with deletion and the RNAi-mediated reduction of subdued show that subdued is required for thermal nociception in nociceptors. Further genetic analysis of subdued mutant and thermo-TRP mutants show that they interact functionally in thermal nociception. We find that Subdued expressed in heterologous cells mediates a strong chloride conductance in the presence of both heat and calcium ions. Therefore, our analysis suggests that Subdued channels may amplify the nociceptive neuronal firing that is initiated by thermo-TRP channels in response to thermal stimuli.
Amer Soc Biochemistry Molecular Biology Inc
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Aging Convergence Research Center > 1. Journal Articles
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