Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice

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dc.contributor.authorW Y Jeon-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorH K Shin-
dc.contributor.authorM Y Lee-
dc.date.accessioned2017-04-19T10:03:56Z-
dc.date.available2017-04-19T10:03:56Z-
dc.date.issued2015-
dc.identifier.issn1472-6882-
dc.identifier.uri10.1186/s12906-015-0561-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12593-
dc.description.abstractBackground: Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. Methods: Female BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulin E (IgE) in BALF and plasma, and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. Results: Our findings indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma, and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells, and the expression of iNOS in lung tissue. Conclusions: Collectively, these results suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of allergic asthma.-
dc.publisherSpringer-BMC-
dc.titleSamsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice-
dc.title.alternativeSamsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice-
dc.typeArticle-
dc.citation.titleBMC Complementary and Alternative Medicine-
dc.citation.number0-
dc.citation.endPage47-
dc.citation.startPage47-
dc.citation.volume15-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.alternativeName전우영-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName신현규-
dc.contributor.alternativeName이미영-
dc.identifier.bibliographicCitationBMC Complementary and Alternative Medicine, vol. 15, pp. 47-47-
dc.identifier.doi10.1186/s12906-015-0561-3-
dc.subject.keywordAsthma-
dc.subject.keywordInflammatory cells-
dc.subject.keywordiNOS-
dc.subject.keywordSamsoeum-
dc.subject.keywordTh1/Th2 cytokines-
dc.subject.localasthma-
dc.subject.localAsthma-
dc.subject.localInflammatory cells-
dc.subject.localInflammatory cell-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localSamsoeum-
dc.subject.localTh1/Th2 cytokines-
dc.description.journalClassY-
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